dc.contributorUniversidade Federal de Minas Gerais (UFMG)
dc.contributorUniversity of Illinois
dc.contributorUniversidade Estadual Paulista (UNESP)
dc.contributorUniversity of Port Harcourt
dc.date.accessioned2022-04-29T08:30:14Z
dc.date.accessioned2022-12-20T02:46:47Z
dc.date.available2022-04-29T08:30:14Z
dc.date.available2022-12-20T02:46:47Z
dc.date.created2022-04-29T08:30:14Z
dc.date.issued2021-07-01
dc.identifierDifferentiation, v. 120, p. 36-47.
dc.identifier1432-0436
dc.identifier0301-4681
dc.identifierhttp://hdl.handle.net/11449/229070
dc.identifier10.1016/j.diff.2021.06.002
dc.identifier2-s2.0-85109036383
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5409204
dc.description.abstractSeminiferous tubules physically connect to the rete testis through short segments called the transition region (TR). During fetal development, this specialized junction is considered the initial site where testis cords begin to form and to grow in length well beyond birth and into adulthood and form convoluted tubular cores. Mitotic activity of the Sertoli cell, the somatic cell of the epithelium, ceases before puberty, but modified Sertoli cells in the TR remain immature and capable of proliferation. This review presents what is known about this specialized region of the testis, with an emphasis on the morphological, molecular and physiological features, which support the hypothesis that this short region of epithelial transition serves as a specialized niche for undifferentiated Sertoli cells and spermatogonial stem cells. Also, the region is populated by an elevated number of immune cells, suggesting an important activity in monitoring and responding to any leakage of autoantigens, as sperm enter the rete testis. Several structure/function characteristics of the transition region are discussed and compared across species.
dc.languageeng
dc.relationDifferentiation
dc.sourceScopus
dc.subjectRete testis
dc.subjectSeminiferous tubules
dc.subjectSertoli cell
dc.subjectSertoli valve
dc.subjectTransition region
dc.subjectTubuli recti
dc.titleInsights into differentiation and function of the transition region between the seminiferous tubule and rete testis
dc.typeOtros


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