Brasil
| Artículos de revistas
The influence of obesity by a diet high in saturated fats and carbohydrates balance in the manifestation of systemic complications and comorbidities
dc.contributor | Universidade Estadual Paulista (UNESP) | |
dc.date.accessioned | 2022-04-29T08:27:51Z | |
dc.date.accessioned | 2022-12-20T02:41:22Z | |
dc.date.available | 2022-04-29T08:27:51Z | |
dc.date.available | 2022-12-20T02:41:22Z | |
dc.date.created | 2022-04-29T08:27:51Z | |
dc.date.issued | 2017-12-01 | |
dc.identifier | Nutrire, v. 42, n. 1, 2017. | |
dc.identifier | 2316-7874 | |
dc.identifier | 1519-8928 | |
dc.identifier | http://hdl.handle.net/11449/228636 | |
dc.identifier | 10.1186/s41110-017-0042-1 | |
dc.identifier | 2-s2.0-85058041300 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/5408771 | |
dc.description.abstract | Background: The aim of this study is to test the hypothesis that obesity induced by a diet rich in saturated fats and balanced in carbohydrates is associated with the development of systemic complications and comorbidities. Methods: Thirty-seven 60-day-old male Wistar rats were randomized into two groups: control (C, n = 18, standard diet) and obese (OB, n = 19, high-saturated fat diet), for 33 weeks. Nutritional profile: food and caloric intake, feed efficiency, body weight, and adiposity index. Complications: in plasma were analyzed dyslipidemia, insulin resistance (HOMA-IR), glucose intolerance, hyperleptinemia, hyperinsulinemia, plasmatic C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α); in the myocardial and epididymal adipose tissue were assessed IL-6 and TNF-α. Comorbidities: diabetes mellitus and systemic blood pressure (SBP). Student’s t test, ANOVA, and Bonferroni P < 0.05. Results: The final body weight, feed efficiency, and adiposity index were higher in OB group than in control; although food intake was lower in OB group, caloric intake was similar in both groups. Specific parameters, such as LDL, cholesterol, triglycerides, HOMA-IR, CRP, TNF-α in epididymal adipose tissue, and IL-6 in the myocardium, were higher in obese rats than in controls. SBP, baseline glucose, and glucose after 2 h of overload were significantly increased in OB group; however, the severity was not enough to classify the animals as diabetic and hypertensive. Conclusion: Obesity induced by a diet high in saturated fatty acids with balanced carbohydrates for 33 weeks in Wistar rats was effective in triggering complications but unable to develop comorbidities. | |
dc.language | eng | |
dc.relation | Nutrire | |
dc.source | Scopus | |
dc.subject | Comorbidities | |
dc.subject | Complications | |
dc.subject | Diet | |
dc.subject | Obesity | |
dc.subject | Rat | |
dc.title | The influence of obesity by a diet high in saturated fats and carbohydrates balance in the manifestation of systemic complications and comorbidities | |
dc.type | Artículos de revistas |