dc.contributor | Universidade Estadual Paulista (UNESP) | |
dc.date.accessioned | 2022-04-28T19:54:15Z | |
dc.date.accessioned | 2022-12-20T01:44:11Z | |
dc.date.available | 2022-04-28T19:54:15Z | |
dc.date.available | 2022-12-20T01:44:11Z | |
dc.date.created | 2022-04-28T19:54:15Z | |
dc.date.issued | 1995-01-01 | |
dc.identifier | Brazilian Journal of Medical and Biological Research, v. 28, n. 2, p. 240-245, 1995. | |
dc.identifier | 0100-879X | |
dc.identifier | http://hdl.handle.net/11449/224001 | |
dc.identifier | 2-s2.0-0028951248 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/5404130 | |
dc.description.abstract | We studied the effect of the α1- and α2-adrenergic receptors of the lateral hypothalamus (LH on the control of water intake induced by injection of carbachol into the medial septal area (MSA) of adult male Holtzman rats (250-300 g) implanted with chronic stainless steel cannulae into the LH and MSA. The volume of injection was always 1 μl and was injected over a period of 30-60 s. For control, 0.15 M NaCl was used. Clonidine (20 nmol) but not phenylephrine (160 nmol) injected into the LH inhibited water intake induced by injection of carbachol (2 nmol) into the MSA, from 5.4 ± l.2 ml/h to 0.3 ± 0.1 and 3.0 ± 0.9 ml/h, respectively (N = 26). When we injected yohimbine (80 nmol) + clonidine (20 nmol) and prazosin (40 nmol) + clonidine (20 nmol) into the LH, water intake induced by injection of carbachol into the MSA was inhibited from 5.4 ± 1.2 ml/h to 0.8 ± 0.5 and 0.3 ± 0.2 ml/h, respectively (N = 19). Water intake induced by carbachol (2 nmol) injected into the MSA was decreased by previous injection of yohimbine (80 nmol) + phenylephrine (160 nmol) and prazosin (40 nmol) + phenylephrine (160 nmol) from 5.4 ± 1.2 ml/h to 1.0 ± 0.7 and 1.8 ± 0.8 ml/h, respectively (N = 16). The cannula reached both the medial septal area in its medial portion and the lateral hypothalamus. It has been suggested that the different pathways for induction of drinking converge on a final common pathway. Thus, adrenergic stimulation of α2-adrenoceptors of LH can influence this final common pathway. | |
dc.language | eng | |
dc.relation | Brazilian Journal of Medical and Biological Research | |
dc.source | Scopus | |
dc.subject | α1- and α2-adrenoceptors | |
dc.subject | cholinergic receptors | |
dc.subject | lateral hypothalamus | |
dc.subject | septal area | |
dc.subject | water intake | |
dc.title | Alpha-adrenergic pathways in the lateral hypothalamus are important for the dipsogenic effect of carbachol injected into the medial septal area | |
dc.type | Artículos de revistas | |