dc.contributorUniversidade Federal de São Carlos (UFSCar)
dc.contributorUniversidade Estadual Paulista (UNESP)
dc.contributorNeuroscience and Behavioral Institute
dc.contributorThe University of Calgary
dc.contributorSchool of Behavior and Brain Sciences
dc.contributorTexas Biomedical Device Center
dc.date.accessioned2022-04-28T19:44:52Z
dc.date.accessioned2022-12-20T01:24:53Z
dc.date.available2022-04-28T19:44:52Z
dc.date.available2022-12-20T01:24:53Z
dc.date.created2022-04-28T19:44:52Z
dc.date.issued2022-01-24
dc.identifierBehavioural Brain Research, v. 417.
dc.identifier1872-7549
dc.identifier0166-4328
dc.identifierhttp://hdl.handle.net/11449/222478
dc.identifier10.1016/j.bbr.2021.113588
dc.identifier2-s2.0-85115660845
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5402608
dc.description.abstractThe monoamine neurotransmitter serotonin (5-HT) modulates anxiety by its activity on 5-HT2C receptors (5-HT2CR) expressed in the dorsal periaqueductal gray (dPAG). Here, we investigated the presence of 5-HT3A receptors (5-HT3AR) in the dPAG, and the interplay between 5-HT2CR and 5-HT3AR in the dPAG in mediating anxiety-like behavior in mice. We found that 5-HT3AR is expressed in the dPAG and the blockade of these receptors using intra-dPAG infusion of ondansetron (5-HT3AR antagonist; 3.0 nmol) induced an anxiogenic-like effect. The activation of 5-HT3ABR by the infusion of mCPBG [1-(m-Chlorophenyl)-biguanide; 5-HT3R agonist] did not alter anxiety-like behaviors. In addition, blockade of 5-HT3AR (1.0 nmol) prevented the anxiolytic-like effect induced by the infusion of the 5-HT2CR agonist mCPP (1-(3-chlorophenyl) piperazine; 0.03 nmol). None of the treatment effects on anxiety-like behaviors altered the locomotor activity levels. The present results suggest that the anxiolytic-like effect exerted by serotonin activity on 5-HT2CR in the dPAG is modulated by 5-HT3AR expressed in same region.
dc.languageeng
dc.relationBehavioural Brain Research
dc.sourceScopus
dc.subject5-HT3A and 5-HT2C receptors
dc.subjectElevated Plus-Maze (EPM)
dc.subjectMCPBG
dc.subjectMCPP
dc.subjectMice
dc.subjectOndansetron
dc.titleThe interplay between 5-HT2C and 5-HT3A receptors in the dorsal periaqueductal gray mediates anxiety-like behavior in mice
dc.typeArtículos de revistas


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