dc.contributor | Universidade Federal de São Carlos (UFSCar) | |
dc.contributor | Universidade Estadual Paulista (UNESP) | |
dc.contributor | Neuroscience and Behavioral Institute | |
dc.contributor | The University of Calgary | |
dc.contributor | School of Behavior and Brain Sciences | |
dc.contributor | Texas Biomedical Device Center | |
dc.date.accessioned | 2022-04-28T19:44:52Z | |
dc.date.accessioned | 2022-12-20T01:24:53Z | |
dc.date.available | 2022-04-28T19:44:52Z | |
dc.date.available | 2022-12-20T01:24:53Z | |
dc.date.created | 2022-04-28T19:44:52Z | |
dc.date.issued | 2022-01-24 | |
dc.identifier | Behavioural Brain Research, v. 417. | |
dc.identifier | 1872-7549 | |
dc.identifier | 0166-4328 | |
dc.identifier | http://hdl.handle.net/11449/222478 | |
dc.identifier | 10.1016/j.bbr.2021.113588 | |
dc.identifier | 2-s2.0-85115660845 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/5402608 | |
dc.description.abstract | The monoamine neurotransmitter serotonin (5-HT) modulates anxiety by its activity on 5-HT2C receptors (5-HT2CR) expressed in the dorsal periaqueductal gray (dPAG). Here, we investigated the presence of 5-HT3A receptors (5-HT3AR) in the dPAG, and the interplay between 5-HT2CR and 5-HT3AR in the dPAG in mediating anxiety-like behavior in mice. We found that 5-HT3AR is expressed in the dPAG and the blockade of these receptors using intra-dPAG infusion of ondansetron (5-HT3AR antagonist; 3.0 nmol) induced an anxiogenic-like effect. The activation of 5-HT3ABR by the infusion of mCPBG [1-(m-Chlorophenyl)-biguanide; 5-HT3R agonist] did not alter anxiety-like behaviors. In addition, blockade of 5-HT3AR (1.0 nmol) prevented the anxiolytic-like effect induced by the infusion of the 5-HT2CR agonist mCPP (1-(3-chlorophenyl) piperazine; 0.03 nmol). None of the treatment effects on anxiety-like behaviors altered the locomotor activity levels. The present results suggest that the anxiolytic-like effect exerted by serotonin activity on 5-HT2CR in the dPAG is modulated by 5-HT3AR expressed in same region. | |
dc.language | eng | |
dc.relation | Behavioural Brain Research | |
dc.source | Scopus | |
dc.subject | 5-HT3A and 5-HT2C receptors | |
dc.subject | Elevated Plus-Maze (EPM) | |
dc.subject | MCPBG | |
dc.subject | MCPP | |
dc.subject | Mice | |
dc.subject | Ondansetron | |
dc.title | The interplay between 5-HT2C and 5-HT3A receptors in the dorsal periaqueductal gray mediates anxiety-like behavior in mice | |
dc.type | Artículos de revistas | |