Brasil | Artículos de revistas
dc.contributorUniversidade Estadual Paulista (UNESP)
dc.contributorDr. Paulo Prata – FACISB
dc.contributorBarretos Cancer Hospital
dc.contributorCiudad Universitaria UNL
dc.contributorUniversity of Illinois at Urbana-Champaign
dc.date.accessioned2022-04-28T19:43:40Z
dc.date.accessioned2022-12-20T01:22:19Z
dc.date.available2022-04-28T19:43:40Z
dc.date.available2022-12-20T01:22:19Z
dc.date.created2022-04-28T19:43:40Z
dc.date.issued2021-10-01
dc.identifierFood and Chemical Toxicology, v. 156.
dc.identifier1873-6351
dc.identifier0278-6915
dc.identifierhttp://hdl.handle.net/11449/222275
dc.identifier10.1016/j.fct.2021.112519
dc.identifier2-s2.0-85113390835
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5402405
dc.description.abstractPhthalates metabolites have been detected in the urine of pregnant and breastfeeding women. Thus, this study evaluated the adverse effects of maternal exposure to a mixture of six phthalates (Pth mix) on the mammary gland development and carcinogenesis in F1 female offspring. Pregnant female Sprague-Dawley rats were exposed daily to vehicle or Pth mix (35.22% diethyl-phthalate, 21.03% di-(2-ethylhexyl)-phthalate, 14.91% dibutyl-phthalate, 15.10% diisononyl-phthalate, 8.61% diisobutyl-phthalate, and 5.13% benzylbutyl-phthalate) by gavage at 20 μg/kg, 200 μg/kg or 200 mg/kg during gestational day 10 (GD 10) to postnatal day 21 (PND 21). After weaning (PND 22), some female offspring were euthanized for mammary gland analyses while other females received a single dose of N-methyl-N-nitrosourea (MNU, 50 mg/kg) or vehicle and then tumor incidence and multiplicity were recorded until PND 180. Maternal Pth mix exposure increased the number of Ki-67 and progesterone receptor-positive epithelial cells in the mammary gland from Pth mix 200 at μg/kg and 200 mg/kg groups. In addition, tumor incidence and mean number were higher only in Pth mix at 200 mg/kg when compared to the vehicle-treated group, and percentage of tumor-free animals was lower in Pth mix at 200 μg/kg and 200 mg/kg groups. The findings indicate that perinatal Pth mixture exposure increased susceptibility to MNU-induced mammary carcinogenesis in adult F1 female offspring.
dc.languageeng
dc.relationFood and Chemical Toxicology
dc.sourceScopus
dc.subjectChemically-induced mammary tumor
dc.subjectF1female offspring
dc.subjectMammary gland development and cancer susceptibility
dc.subjectPhthalate mixture
dc.titlePrenatal exposure to a mixture of different phthalates increases the risk of mammary carcinogenesis in F1 female offspring
dc.typeArtículos de revistas


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