Brasil
| Artículos de revistas
Prenatal exposure to a mixture of different phthalates increases the risk of mammary carcinogenesis in F1 female offspring
dc.contributor | Universidade Estadual Paulista (UNESP) | |
dc.contributor | Dr. Paulo Prata – FACISB | |
dc.contributor | Barretos Cancer Hospital | |
dc.contributor | Ciudad Universitaria UNL | |
dc.contributor | University of Illinois at Urbana-Champaign | |
dc.date.accessioned | 2022-04-28T19:43:40Z | |
dc.date.accessioned | 2022-12-20T01:22:19Z | |
dc.date.available | 2022-04-28T19:43:40Z | |
dc.date.available | 2022-12-20T01:22:19Z | |
dc.date.created | 2022-04-28T19:43:40Z | |
dc.date.issued | 2021-10-01 | |
dc.identifier | Food and Chemical Toxicology, v. 156. | |
dc.identifier | 1873-6351 | |
dc.identifier | 0278-6915 | |
dc.identifier | http://hdl.handle.net/11449/222275 | |
dc.identifier | 10.1016/j.fct.2021.112519 | |
dc.identifier | 2-s2.0-85113390835 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/5402405 | |
dc.description.abstract | Phthalates metabolites have been detected in the urine of pregnant and breastfeeding women. Thus, this study evaluated the adverse effects of maternal exposure to a mixture of six phthalates (Pth mix) on the mammary gland development and carcinogenesis in F1 female offspring. Pregnant female Sprague-Dawley rats were exposed daily to vehicle or Pth mix (35.22% diethyl-phthalate, 21.03% di-(2-ethylhexyl)-phthalate, 14.91% dibutyl-phthalate, 15.10% diisononyl-phthalate, 8.61% diisobutyl-phthalate, and 5.13% benzylbutyl-phthalate) by gavage at 20 μg/kg, 200 μg/kg or 200 mg/kg during gestational day 10 (GD 10) to postnatal day 21 (PND 21). After weaning (PND 22), some female offspring were euthanized for mammary gland analyses while other females received a single dose of N-methyl-N-nitrosourea (MNU, 50 mg/kg) or vehicle and then tumor incidence and multiplicity were recorded until PND 180. Maternal Pth mix exposure increased the number of Ki-67 and progesterone receptor-positive epithelial cells in the mammary gland from Pth mix 200 at μg/kg and 200 mg/kg groups. In addition, tumor incidence and mean number were higher only in Pth mix at 200 mg/kg when compared to the vehicle-treated group, and percentage of tumor-free animals was lower in Pth mix at 200 μg/kg and 200 mg/kg groups. The findings indicate that perinatal Pth mixture exposure increased susceptibility to MNU-induced mammary carcinogenesis in adult F1 female offspring. | |
dc.language | eng | |
dc.relation | Food and Chemical Toxicology | |
dc.source | Scopus | |
dc.subject | Chemically-induced mammary tumor | |
dc.subject | F1female offspring | |
dc.subject | Mammary gland development and cancer susceptibility | |
dc.subject | Phthalate mixture | |
dc.title | Prenatal exposure to a mixture of different phthalates increases the risk of mammary carcinogenesis in F1 female offspring | |
dc.type | Artículos de revistas |