Morphological Changes in the Myotendinous Junction of mdx Mice

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.contributorUniversidade de São Paulo (USP)
dc.date.accessioned2022-04-28T19:43:35Z
dc.date.accessioned2022-12-20T01:22:04Z
dc.date.available2022-04-28T19:43:35Z
dc.date.available2022-12-20T01:22:04Z
dc.date.created2022-04-28T19:43:35Z
dc.date.issued2021-10-17
dc.identifierMicroscopy and Microanalysis, v. 27, n. 5, p. 1290-1294, 2021.
dc.identifier1435-8115
dc.identifier1431-9276
dc.identifierhttp://hdl.handle.net/11449/222253
dc.identifier10.1017/S1431927621012496
dc.identifier2-s2.0-85113186771
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5402383
dc.description.abstractThe myotendinous junction (MTJ) is the interface between muscle and tendon, and it is the main area of force transmission of the locomotor apparatus. Dystrophic processes promote pathological injury which affects the skeletal muscle and can influence the morphology of the MTJ. This study aimed to investigate the adaptations in MTJ morphology of mdx mice in the tibialis anterior muscle. Male mice (n = 24) were divided into Control-C57bl/10 and mdx-C57bl/10mdx (Duchenne muscular dystrophy experimental model). In the mdx group, centralized nuclei with a large area and greater deposition of type III collagen (fibrosis) were observed. Also, shorter sarcomeres and sarcoplasmatic projections of MTJ were observed. We concluded that the adaptations in mdx mice demonstrated extensive impairment in the MTJ region with reduced ultrastructures.
dc.languageeng
dc.relationMicroscopy and Microanalysis
dc.sourceScopus
dc.subjectDuchenne muscular dystrophy
dc.subjectfibrosis
dc.subjectfinger-like process
dc.subjectmuscle degeneration
dc.subjectsarcomere
dc.titleMorphological Changes in the Myotendinous Junction of mdx Mice
dc.typeArtículos de revistas


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