dc.contributor | Universidade Federal do Rio Grande do Sul | |
dc.contributor | PUCRS | |
dc.contributor | Universidade Federal do Maranhão | |
dc.contributor | Universidade Federal de Mato Grosso | |
dc.contributor | Hospital de Base | |
dc.contributor | Universidade Federal de Pernambuco (UFPE) | |
dc.contributor | Hospital do Coração | |
dc.contributor | Universidade Federal de Minas Gerais (UFMG) | |
dc.contributor | Universidade Federal do Ceará | |
dc.contributor | Instituto de Cardiologia | |
dc.contributor | Universidade de São Paulo (USP) | |
dc.contributor | Universidade Federal de Goiás (UFG) | |
dc.contributor | Instituto de Medicina Integral Prof. Fernando Figueira | |
dc.contributor | Universidade Federal de Pelotas | |
dc.contributor | Universidade do Estado do Rio de Janeiro (UERJ) | |
dc.contributor | Hospital do Coração Anis Rassi | |
dc.contributor | Universidade Federal Fluminense (UFF) | |
dc.contributor | Universidade Estadual Paulista (UNESP) | |
dc.contributor | Hospital Universitário PROCAPE | |
dc.contributor | Tulane University School of Public Health and Tropical Medicine | |
dc.contributor | Research Institute HC or Hospital do Coração | |
dc.date.accessioned | 2022-04-28T19:09:40Z | |
dc.date.accessioned | 2022-12-20T01:07:44Z | |
dc.date.available | 2022-04-28T19:09:40Z | |
dc.date.available | 2022-12-20T01:07:44Z | |
dc.date.created | 2022-04-28T19:09:40Z | |
dc.date.issued | 2018-04-01 | |
dc.identifier | Journal of Hypertension, v. 36, n. 4, p. 933-938, 2018. | |
dc.identifier | 1473-5598 | |
dc.identifier | 0263-6352 | |
dc.identifier | http://hdl.handle.net/11449/221112 | |
dc.identifier | 10.1097/HJH.0000000000001624 | |
dc.identifier | 2-s2.0-85049680825 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/5401240 | |
dc.description.abstract | Background: To determine the effectiveness of low-dose diuretic therapy to achieve an optimal level of blood pressure (BP) in adults with prehypertension. Methods: The PREVER-prevention trial was a randomized, parallel, double-blinded, placebo-controlled trial, with 18 months of follow-up, conducted at 21 academic medical centers in Brazil. Of 1772 individuals evaluated for eligibility, 730 volunteers with prehypertension who were aged 30-70 years, and who did not reach optimal blood pressure after 3 months of lifestyle intervention, were randomized to a fixed association of chlorthalidone 12.5mg and amiloride 2.5mg or placebo once a day. The main outcomes were the percentage of participants who achieved an optimal level of BP. Results: A total of 372 participants were randomly allocated to diuretics and 358 to placebo. After 18 months of treatment, optimal BP was noted in 25.6% of the diuretic group and 19.3% in the placebo group (P<0.05). The mean net reduction in SBP and DBP for the diuretic group compared with placebo was 2.8mmHg (95% CI 1.1 to 4.5) and 1.1mmHg (95% CI -0.09 to 2.4), respectively. Most participants in the active treatment group (74.5%) and in the placebo group (80.7%) continued to have BP in the prehypertension range or progressed to hypertension. Conclusion: Low-dose diuretic therapy increased the probability of individuals with prehypertension to achieve optimal BP but most of those treated continued to have a BP in the prehypertension range or progressed to having overt hypertension. | |
dc.language | eng | |
dc.relation | Journal of Hypertension | |
dc.source | Scopus | |
dc.subject | Chlorthalidone and amiloride | |
dc.subject | Clinical trials | |
dc.subject | Hypertension | |
dc.subject | Optimal blood pressure | |
dc.subject | Prehypertension | |
dc.title | Effectiveness of low-dose diuretics for blood pressure reduction to optimal values in prehypertension: A randomizedclinical trial | |
dc.type | Artículos de revistas | |