Promising Ag(I) complexes with N-acylhydrazones from aromatic aldehydes and isoniazid against multidrug resistance in tuberculosis

dc.contributorFederal University of Juiz de Fora – UFJF
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Estadual de Campinas (UNICAMP)
dc.contributorUniversidade Federal de Uberlândia (UFU)
dc.contributorFederal University of Mato Grosso – UFMT
dc.date.accessioned2021-06-25T11:12:49Z
dc.date.accessioned2022-12-19T22:41:26Z
dc.date.available2021-06-25T11:12:49Z
dc.date.available2022-12-19T22:41:26Z
dc.date.created2021-06-25T11:12:49Z
dc.date.issued2021-06-15
dc.identifierJournal of Molecular Structure, v. 1234.
dc.identifier0022-2860
dc.identifierhttp://hdl.handle.net/11449/208478
dc.identifier10.1016/j.molstruc.2021.130193
dc.identifier2-s2.0-85102039591
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5389075
dc.description.abstractIn the present work, synthesis, characterization and antitubercular assays of N-acylhydrazones derivatives and their corresponding silver(I) complexes are described. The compounds were characterized by elemental analysis, IR and NMR spectroscopic measurements, molar conductivity assays and powder diffraction X ray studies. Some of the synthesized compounds have shown minimum inhibitory concentration (MIC90) values against M. tuberculosis H37Rv (ATCC 27294) lower than 0.098 µg/mL, while the cytotoxic activity assays over MRC-5 cells reveled that all compounds present selectivity indexes higher than 27. Furthermore, N-acylhydrazones compounds showed promising activities even against multidrug-resistant clinical strains of M. tuberculosis.
dc.languageeng
dc.relationJournal of Molecular Structure
dc.sourceScopus
dc.subjectMycobacterium tuberculosis
dc.subjectN-acylhydrazones
dc.subjectPowder X-ray diffraction
dc.subjectSilver complexes
dc.titlePromising Ag(I) complexes with N-acylhydrazones from aromatic aldehydes and isoniazid against multidrug resistance in tuberculosis
dc.typeArtículos de revistas


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