Alzheimer's disease: Related targets, synthesis of available drugs, bioac-tive compounds under development and promising results obtained from multi-target approaches

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorFederal University of Alfenas
dc.contributorUniversity of Victo-ria
dc.date.accessioned2021-06-25T10:57:56Z
dc.date.accessioned2022-12-19T22:31:05Z
dc.date.available2021-06-25T10:57:56Z
dc.date.available2022-12-19T22:31:05Z
dc.date.created2021-06-25T10:57:56Z
dc.date.issued2021-01-01
dc.identifierCurrent Drug Targets, v. 22, n. 5, p. 505-538, 2021.
dc.identifier1873-5592
dc.identifier1389-4501
dc.identifierhttp://hdl.handle.net/11449/207603
dc.identifier10.2174/1389450121999200819144544
dc.identifier2-s2.0-85104194121
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5388200
dc.description.abstractWe describe herein the therapeutic targets involved in Alzheimer’s disease as well as the available drugs and their synthetic routes. Bioactive compounds under development are also exploited to illustrate some recent research advances on the medicinal chemistry of Alzheimer’s disease, including structure-activity relationships for some targets. The importance of multi-target approaches, including some examples from our research projects, guides new perspectives in search of more effective drug candidates. This review comprises the period between 2001 and early 2020.
dc.languageeng
dc.relationCurrent Drug Targets
dc.sourceScopus
dc.subjectAcetylcholinesterase
dc.subjectAlzheimer’s disease
dc.subjectMulti-target-directed ligands
dc.subjectNicotinic acetylcholine receptors
dc.subjectStructure-activity relationship
dc.subjectSynthetic routes
dc.titleAlzheimer's disease: Related targets, synthesis of available drugs, bioac-tive compounds under development and promising results obtained from multi-target approaches
dc.typeArtículos de revistas


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