dc.contributor | University of Washington School of Medicine | |
dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Ann & Robert H. Lurie Children’s Hospital of Chicago | |
dc.contributor | Northwestern University Feinberg School of Medicine | |
dc.date.accessioned | 2021-06-25T10:36:44Z | |
dc.date.accessioned | 2022-12-19T22:20:15Z | |
dc.date.available | 2021-06-25T10:36:44Z | |
dc.date.available | 2022-12-19T22:20:15Z | |
dc.date.created | 2021-06-25T10:36:44Z | |
dc.date.issued | 2020-11-01 | |
dc.identifier | Physiology, v. 35, n. 6, p. 375-390, 2020. | |
dc.identifier | 1548-9221 | |
dc.identifier | 1548-9213 | |
dc.identifier | http://hdl.handle.net/11449/206700 | |
dc.identifier | 10.1152/physiol.00008.2020 | |
dc.identifier | 2-s2.0-85092886147 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/5387297 | |
dc.description.abstract | Rett syndrome (RTT), an X-chromosome-linked neurological disorder, is characterized by serious pathophysiology, including breathing and feeding dysfunctions, and alteration of cardiorespiratory coupling, a consequence of multiple interrelated disturbances in the genetic and homeostatic regulation of central and peripheral neuronal networks, redox state, and control of inflammation. Characteristic breath-holds, obstructive sleep apnea, and aerophagia result in intermittent hypoxia, which, combined with mitochondrial dysfunction, causes oxidative stress-an important driver of the clinical presentation of RTT. | |
dc.language | eng | |
dc.relation | Physiology | |
dc.source | Scopus | |
dc.subject | Autonomic dysregulation | |
dc.subject | Breathing | |
dc.subject | Dysphagia | |
dc.subject | Oxidative stress | |
dc.title | The pathophysiology of rett syndrome with a focus on breathing dysfunctions | |
dc.type | Artículos de revistas | |