Improving the Potency of N-Aryl-2,5-dimethylpyrroles against Multidrug-Resistant and Intracellular Mycobacteria

dc.contributorKing's College London
dc.contributorChimica e Farmacia
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversity College London
dc.contributorUniversity of London
dc.contributorBar-Ilan University
dc.date.accessioned2020-12-12T02:32:59Z
dc.date.accessioned2022-12-19T21:16:41Z
dc.date.available2020-12-12T02:32:59Z
dc.date.available2022-12-19T21:16:41Z
dc.date.created2020-12-12T02:32:59Z
dc.date.issued2020-05-14
dc.identifierACS Medicinal Chemistry Letters, v. 11, n. 5, p. 638-644, 2020.
dc.identifier1948-5875
dc.identifierhttp://hdl.handle.net/11449/201456
dc.identifier10.1021/acsmedchemlett.9b00515
dc.identifier2-s2.0-85077653042
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5382090
dc.description.abstractA series of N-phenyl-2,5-dimethylpyrrole derivatives, designed as hybrids of the antitubercular agents BM212 and SQ109, have been synthesized and evaluated against susceptible and drug-resistant mycobacteria strains. Compound 5d, bearing a cyclohexylmethylene side chain, showed high potency against M. tuberculosis including MDR-TB strains at submicromolar concentrations. The new compound shows bacteriostatic activity and low toxicity and proved to be effective against intracellular mycobacteria too, showing an activity profile similar to isoniazid.
dc.languageeng
dc.relationACS Medicinal Chemistry Letters
dc.sourceScopus
dc.subjectantimycobacterial drug
dc.subjectdrug resistance
dc.subjectintracellular tuberculosis
dc.subjectpyrroles
dc.subjectTuberculosis
dc.titleImproving the Potency of N-Aryl-2,5-dimethylpyrroles against Multidrug-Resistant and Intracellular Mycobacteria
dc.typeArtículos de revistas


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