dc.contributor | UFT | |
dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Universidade de São Paulo (USP) | |
dc.contributor | Institute of Botany - Plant Biochemistry and Physiology Section | |
dc.contributor | UFPI | |
dc.date.accessioned | 2020-12-12T02:18:32Z | |
dc.date.accessioned | 2022-12-19T21:09:41Z | |
dc.date.available | 2020-12-12T02:18:32Z | |
dc.date.available | 2022-12-19T21:09:41Z | |
dc.date.created | 2020-12-12T02:18:32Z | |
dc.date.issued | 2020-10-01 | |
dc.identifier | Phytochemistry Letters, v. 39, p. 116-123. | |
dc.identifier | 1876-7486 | |
dc.identifier | 1874-3900 | |
dc.identifier | http://hdl.handle.net/11449/200879 | |
dc.identifier | 10.1016/j.phytol.2020.07.016 | |
dc.identifier | 2-s2.0-85089242805 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/5381513 | |
dc.description.abstract | Three new oxygenated cyclohexanoids, namely, speciosin U (1), speciosin V (2) and speciosin W (3), along with four known compounds consisting of 4-hydroxy-3-(3′-methylbut-3′-en-1′-ynyl)-benzoic acid (4), 4-hydroxy-3-prenyl-benzoic acid (5), 2,2-dimethyl-2H-chromene-6-carboxylic acid (6) and trans-3,4-dihydro-3,4-dihydroxy-anofinic acid (7) were isolated from scale-up cultures of Saccharicola sp., an endophyte of Eugenia jambolana. The structures were established by analysis of spectroscopic data, including 1D and 2D NMR. The absolute configuration of 1 was determined using Mosher's method. Speciosin U (1) and trans-3,4-dihydro-3,4-dihydroxy-anofinic acid (7) exhibited a potent acetylcholinesterase (AChE) inhibitory activity comparable to reference inhibitor galantamine. Furthermore, speciosin U (1) presented antifungal activity invitro against the phytopathogenic fungi Cladosporium cladosporioides, while compounds 4-hydroxy-3-(3′-methylbut-3′-en-1′-ynyl)-benzoic acid (4) and 4-hydroxy-3-prenyl-benzoic acid (5) exhibited antifungal activity against C. sphaerospermum. | |
dc.language | eng | |
dc.relation | Phytochemistry Letters | |
dc.source | Scopus | |
dc.subject | AchE inhibitory activity | |
dc.subject | Cyclohexanoids | |
dc.subject | Endophytic fungi | |
dc.subject | Eugenia jambolana | |
dc.subject | Saccharicola sp. | |
dc.subject | Speciosins | |
dc.title | Acetylcholinesterase inhibition and antifungal activity of cyclohexanoids from the endophytic fungus Saccharicola sp. | |
dc.type | Artículos de revistas | |