dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversity of Western São Paulo-UNOESTE
dc.contributorUniversity of Guelph
dc.contributorUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2020-12-12T01:55:21Z
dc.date.accessioned2022-12-19T20:59:30Z
dc.date.available2020-12-12T01:55:21Z
dc.date.available2022-12-19T20:59:30Z
dc.date.created2020-12-12T01:55:21Z
dc.date.issued2020-01-29
dc.identifierLipids in Health and Disease, v. 19, n. 1, 2020.
dc.identifier1476-511X
dc.identifierhttp://hdl.handle.net/11449/200015
dc.identifier10.1186/s12944-020-1195-0
dc.identifier2-s2.0-85078689096
dc.identifier5760560970751598
dc.identifier0000-0003-1452-5708
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5380649
dc.description.abstractBackground: Altered lipid metabolism is an important characteristic of neoplastic cells, with androgens and growth factors being major regulatory agents of the lipid metabolism process. We investigated the effect of physical resistance training on lipid metabolism and apoptosis in the adult Wistar rat prostate. Methods: Two experimental groups represented sedentary and physical resistance training. Three days per week for 13 weeks, rats performed jumps in water carrying a weight load strapped to their chests as part of a physical resistance exercise protocol. Two days after the last training session, rats were anesthetized and sacrificed for blood and prostate analysis. Results: Physical exercise improved feeding efficiency, decreased weight gain, regulated the serum-lipid profile, and modulated insulin-like growth factor-1 (IGF-1) and free testosterone concentration. Furthermore, upregulation of cluster of differentiation 36 (CD36), sterol regulatory element binding protein-1 (SREBP-1), sterol regulatory element-binding protein cleavage-activating protein (SCAP), and reduced lysosome membrane protein (LIMPII) expression were also observed in the blood and prostates of trained rats. Consistent with these results, caspase-3 expression was upregulating and the BCL-2/Bax index ratio was decreased in trained rats relative to sedentary animals. Conclusions: In this work, physical resistance training can alter lipid metabolism and increase markers of apoptosis in the prostate, suggesting physical resistance training as a potential novel therapeutic strategy for treating prostate cancer.
dc.languageeng
dc.relationLipids in Health and Disease
dc.sourceScopus
dc.subjectApoptosis
dc.subjectCD36
dc.subjectPhysical exercise
dc.subjectSCAP
dc.subjectSREBP-1
dc.titlePhysical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate
dc.typeArtículos de revistas


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