dc.contributorUniversidade Federal do Paraná (UFPR)
dc.contributorUniversidade Federal de Minas Gerais (UFMG)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T17:14:57Z
dc.date.accessioned2022-12-19T19:07:31Z
dc.date.available2019-10-06T17:14:57Z
dc.date.available2022-12-19T19:07:31Z
dc.date.created2019-10-06T17:14:57Z
dc.date.issued2019-06-01
dc.identifierToxins, v. 11, n. 6, 2019.
dc.identifier2072-6651
dc.identifierhttp://hdl.handle.net/11449/190491
dc.identifier10.3390/toxins11060355
dc.identifier2-s2.0-85068959388
dc.identifier9162508978945887
dc.identifier0000-0003-2460-1145
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5371529
dc.description.abstractBrown spider envenomation results in dermonecrosis with gravitational spreading characterized by a marked inflammatory reaction and with lower prevalence of systemic manifestations such as renal failure and hematological disturbances. Several toxins make up the venom of these species, and they are mainly peptides and proteins ranging from 5–40 kDa. The venoms have three major families of toxins: Phospholipases-D, astacin-like metalloproteases, and the inhibitor cystine knot (ICK) peptides. Serine proteases, serpins, hyaluronidases, venom allergens, and a translationally controlled tumor protein (TCTP) are also present. Toxins hold essential biological properties that enable interactions with a range of distinct molecular targets. Therefore, the application of toxins as research tools and clinical products motivates repurposing their uses of interest. This review aims to discuss possibilities for brown spider venom toxins as putative models for designing molecules likely for therapeutics based on the status quo of brown spider venoms. Herein, we explore new possibilities for the venom components in the context of their biochemical and biological features, likewise their cellular targets, three-dimensional structures, and mechanisms of action.
dc.languageeng
dc.relationToxins
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectBiotools
dc.subjectBrown spider
dc.subjectDrug targets
dc.subjectLoxosceles
dc.subjectNovel therapeutics
dc.subjectToxins
dc.subjectVenom
dc.titleBrown spider (Loxosceles) venom toxins as potential biotools for the development of novel therapeutics
dc.typeOtros


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