dc.contributor | Imperial College London | |
dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | University of London | |
dc.contributor | International AIDS Vaccine Initiative Human Immunology Laboratory | |
dc.contributor | London School of Hygiene and Tropical Medicine | |
dc.contributor | Cardiff University School of Medicine | |
dc.contributor | University of Oxford | |
dc.contributor | Oxford NIHR Biomedical Research Centre | |
dc.contributor | University of Cambridge | |
dc.contributor | Frederick National Laboratory for Cancer Research | |
dc.contributor | Johns Hopkins University | |
dc.contributor | Rho | |
dc.contributor | San Francisco Department of Public Health | |
dc.contributor | University of Southampton | |
dc.contributor | National Cancer Institute | |
dc.contributor | MIT and Harvard | |
dc.date.accessioned | 2019-10-06T16:55:02Z | |
dc.date.accessioned | 2022-12-19T19:00:04Z | |
dc.date.available | 2019-10-06T16:55:02Z | |
dc.date.available | 2022-12-19T19:00:04Z | |
dc.date.created | 2019-10-06T16:55:02Z | |
dc.date.issued | 2018-01-01 | |
dc.identifier | Science Immunology, v. 3, n. 29, 2018. | |
dc.identifier | 2470-9468 | |
dc.identifier | http://hdl.handle.net/11449/189875 | |
dc.identifier | 10.1126/sciimmunol.aao2892 | |
dc.identifier | 2-s2.0-85056420369 | |
dc.identifier | 8286209184527011 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/5370913 | |
dc.description.abstract | Killer cell immunoglobulin-like receptors (KIRs) are expressed predominantly on natural killer cells, where they play a key role in the regulation of innate immune responses. Recent studies show that inhibitory KIRs can also affect adaptive T cell–mediated immunity. In mice and in human T cells in vitro, inhibitory KIR ligation enhanced CD8+ T cell survival. To investigate the clinical relevance of these observations, we conducted an extensive immunogenetic analysis of multiple independent cohorts of HIV-1–, hepatitis C virus (HCV)–, and human T cell leukemia virus type 1 (HTLV-1)–infected individuals in conjunction with in vitro assays of T cell survival, analysis of ex vivo KIR expression, and mathematical modeling of host-virus dynamics. Our data suggest that functional engagement of inhibitory KIRs enhances the CD8+ T cell response against HIV-1, HCV, and HTLV-1 and is a significant determinant of clinical outcome in all three viral infections. | |
dc.language | eng | |
dc.relation | Science Immunology | |
dc.rights | Acesso aberto | |
dc.source | Scopus | |
dc.title | Inhibitory killer cell immunoglobulin-like receptors strengthen CD8+ T cell–mediated control of HIV-1, HCV, and HTLV-1 | |
dc.type | Artículos de revistas | |