Circulating HO-1 levels are not associated with plasma sFLT-1 and GT n HMOX1 polymorphism in preeclampsia

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.date.accessioned2019-10-06T16:19:52Z
dc.date.accessioned2022-12-19T18:47:19Z
dc.date.available2019-10-06T16:19:52Z
dc.date.available2022-12-19T18:47:19Z
dc.date.created2019-10-06T16:19:52Z
dc.date.issued2019-04-03
dc.identifierHypertension in Pregnancy, v. 38, n. 2, p. 73-77, 2019.
dc.identifier1525-6065
dc.identifier1064-1955
dc.identifierhttp://hdl.handle.net/11449/188808
dc.identifier10.1080/10641955.2019.1582664
dc.identifier2-s2.0-85062514252
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5369846
dc.description.abstractObjectives: We aimed to assess the plasma HO-1 level and its interrelationship with the plasma sFLT-1 level in preeclamptic and healthy pregnant women with different variants of microsatellite polymorphism (GTn) located in the promoter region of the HMOX-1 gene. Methods: HO-1 and sFLT-1 were measured by ELISA. HMOX1 genotyping was performed using fragment analysis. Results: We found similar and higher levels of plasma HO-1 and sFLT-1, respectively, in preeclampsia. Similar genotypes and alleles frequencies were found in both groups and the absence of modulation of HO-1 levels by genotypes were observed. Conclusion: The plasma HO-1 levels are not increased in preeclampsia women and neither related to sFLT-1 levels and GT n polymorphism.
dc.languageeng
dc.relationHypertension in Pregnancy
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectHMOX1 genotyping
dc.subjectoxidative stress
dc.subjectplasma HO-1
dc.subjectplasma sFLT-1
dc.subjectpolymorphism
dc.subjectPreeclampsia
dc.titleCirculating HO-1 levels are not associated with plasma sFLT-1 and GT n HMOX1 polymorphism in preeclampsia
dc.typeArtículos de revistas


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