Genotoxicity of textile dye C.I. Disperse Blue 291 in mouse bone marrow

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2019-10-06T16:01:15Z
dc.date.accessioned2022-12-19T18:40:26Z
dc.date.available2019-10-06T16:01:15Z
dc.date.available2022-12-19T18:40:26Z
dc.date.created2019-10-06T16:01:15Z
dc.date.issued2019-01-01
dc.identifierMutation Research - Genetic Toxicology and Environmental Mutagenesis, v. 837, p. 48-51.
dc.identifier1879-3592
dc.identifier1383-5718
dc.identifierhttp://hdl.handle.net/11449/188225
dc.identifier10.1016/j.mrgentox.2018.10.003
dc.identifier2-s2.0-85055038472
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5369263
dc.description.abstractColor Index (C.I.) Disperse Blue 291 (DB291) is an azo dye used by the textile industry. After yarn dyeing, wastewater containing the dye, released into the aquatic environment, may pollute drinking water sources. We investigated the mutagenicity and genotoxicity of DB291 in male Swiss mice, following oral administration. Micronucleated cells, primary DNA damage (comet assay) in blood, liver, and kidney cells, and BAX, BCL2, SMAD4 and TNFA gene expression in leukocytes were evaluated. An increased frequency of micronucleated polychromatic erythrocytes (MNPCEs) was observed in animals treated with 50 mg/kg bw; no other genetic alteration was detected. Neither primary DNA damage nor changes in gene expression were observed.
dc.languageeng
dc.relationMutation Research - Genetic Toxicology and Environmental Mutagenesis
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectAzo dye
dc.subjectComet assay
dc.subjectMicronucleus assay
dc.titleGenotoxicity of textile dye C.I. Disperse Blue 291 in mouse bone marrow
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución