Brasil | Artículos de revistas
dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T15:39:36Z
dc.date.accessioned2022-12-19T18:32:16Z
dc.date.available2019-10-06T15:39:36Z
dc.date.available2022-12-19T18:32:16Z
dc.date.created2019-10-06T15:39:36Z
dc.date.issued2019-01-01
dc.identifierLasers in Medical Science.
dc.identifier1435-604X
dc.identifier0268-8921
dc.identifierhttp://hdl.handle.net/11449/187545
dc.identifier10.1007/s10103-019-02771-y
dc.identifier2-s2.0-85064171476
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5368583
dc.description.abstractIn order to purposely decrease the time of the photodynamic therapy (PDT) sessions, this study evaluated the effects of PDT using topical and intradermal delivery of two protoporphyrin (PpIX) precursors with intense pulsed light (IPL) as irradiation source. This study was performed on porcine skin model, using an IPL commercial device (Intense Pulse Light, HKS801). IPL effect on different administration methods of two PpIX precursors (ALA and MAL) was investigated: a topical cream application and an intradermal application using a needle-free, high-pressure injection system. Fluorescence investigation showed that PpIX distribution by needle-free injection was more homogeneous than that by cream, suggesting that a shorter drug-light interval in PDT protocols is possible. The damage induced by IPL-PDT assessed by histological analysis mostly shows modifications in collagens fibers and inflammation signals, both expected for PDT. This study suggested an alternative protocol for the PDT treatment, possibility half of the incubation time and with just 3 min of irradiation, making the IPL-PDT, even more, promising for the clinical treatment.
dc.languageeng
dc.relationLasers in Medical Science
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectAminolevulinic acid
dc.subjectIntense pulsed light
dc.subjectMethyl aminolevulinate
dc.subjectPhotodynamic therapy
dc.subjectPorcine skin
dc.titleTopical and intradermal delivery of PpIX precursors for photodynamic therapy with intense pulsed light on porcine skin model
dc.typeArtículos de revistas


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