Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T15:24:45Z
dc.date.accessioned2022-12-19T18:26:36Z
dc.date.available2019-10-06T15:24:45Z
dc.date.available2022-12-19T18:26:36Z
dc.date.created2019-10-06T15:24:45Z
dc.date.issued2019-01-15
dc.identifierEuropean Journal of Medicinal Chemistry, v. 162, p. 378-395.
dc.identifier1768-3254
dc.identifier0223-5234
dc.identifierhttp://hdl.handle.net/11449/187074
dc.identifier10.1016/j.ejmech.2018.11.013
dc.identifier2-s2.0-85056663289
dc.identifier9734333607975413
dc.identifier0000-0003-4141-0455
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5368112
dc.description.abstractThiazole, thiosemicarbazone and semicarbazone moieties are privileged scaffolds (acting as primary pharmacophores) in many compounds that are useful to treat several diseases, mainly tropical infectious diseases. In this review article, we critically analyzed the contribution of these scaffolds to medicinal chemistry in the last five years, focusing on tropical infectious diseases, such as Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria. We also present perspectives for their use in drug design in order to contribute to the development of new drugs.
dc.languageeng
dc.relationEuropean Journal of Medicinal Chemistry
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectChagas disease
dc.subjectDrug development
dc.subjectNew drugs
dc.subjectSemicarbazone
dc.subjectT. cruzi
dc.subjectThiazole
dc.subjectThiosemicarbazone
dc.titleThiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria
dc.typeOtros


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