dc.contributorUniv Nova Lisboa
dc.contributorEscola Super Agr Elvas
dc.contributorUniv Lisbon
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-04T12:35:12Z
dc.date.accessioned2022-12-19T18:06:30Z
dc.date.available2019-10-04T12:35:12Z
dc.date.available2022-12-19T18:06:30Z
dc.date.created2019-10-04T12:35:12Z
dc.date.issued2019-01-01
dc.identifierCellular Immunology. San Diego: Academic Press Inc Elsevier Science, v. 335, p. 76-84, 2019.
dc.identifier0008-8749
dc.identifierhttp://hdl.handle.net/11449/185400
dc.identifier10.1016/j.cellimm.2018.11.003
dc.identifierWOS:000457737400010
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5366452
dc.description.abstractNeutrophils are short-lived phagocytic cells equipped with several receptors for pathogen recognition and phagocytosis and have intracellular and extracellular effector mechanisms that can inactivate pathogens. Leishmaniases are diseases caused by different species of Leishmania that mainly afflicts poorer populations of tropical and subtropical regions and immunocompromised individuals. Thus, the present study aims to investigate the effector response of murine neutrophils to species of Leishmania causing American cutaneous leishmaniasis and zoonotic visceral leishmaniasis by evaluating pattern recognition receptors (PRR) and intracellular and extracellular effector microbicide activity. When exposed to Leishmania parasites, mouse neutrophils produced superoxide, released enzymes in the extracellular space and generated neutrophil extracellular traps, although PRR gene expression is negatively regulated. L. infantum, L. guyanensis, and L. shawi inhibited enzymatic activity, whereas L. amazonensis reduced the emission of extracellular structures. These findings indicate that although neutrophils trigger several microbicide mechanisms, Leishmania parasites can manipulate extracellular effector mechanisms. The present study also provides evidence that neutrophils can internalize parasites by coiling phagocytosis.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationCellular Immunology
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectInnate immunity
dc.subjectMouse neutrophils
dc.subjectPattern recognition receptors
dc.subjectPhagocytosis
dc.subjectOxidative burst
dc.subjectDegranulation
dc.subjectNeutrophil extracellular traps
dc.subjectLeishmania spp.
dc.titleIntracellular and extracellular effector activity of mouse neutrophils in response to cutaneous and visceral Leishmania parasites
dc.typeArtículos de revistas


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