The Great Role of Klotho

El gran papel de Klotho;
O grande papel de Klotho

dc.creatorDelgado Troche, Fabiana Verónica
dc.date2021-12-31
dc.date.accessioned2022-12-15T18:29:14Z
dc.date.available2022-12-15T18:29:14Z
dc.identifierhttps://revistas.unimilitar.edu.co/index.php/rmed/article/view/5021
dc.identifier10.18359/rmed.5021
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5357502
dc.descriptionKlotho is a single-pass transmembrane protein consisting of 1012 amino acids and expressed strongly and weakly in proximal and distal tubular renal epithelial cells, respectively. There are four groups of Klotho proteins. The α Klotho gene is abundantly expressed in the kidneys, parathyroid glands, choroid plexus, and also in the cerebral cortex, spinal cord, cerebellum, hypothalamus, pituitary, parathyroid glands, ovary, testes, epithelial cells of the sinus, placenta, pancreas, inner ear, vascular smooth muscle cells or intestine. KLOTHO exhibits multiple functions, in addition to phosphate excretion, including enhancing oxidative stress and inhibiting signaling pathways for insulin growth factor, Wnt / β-catenin, transformation of growth factor -β1, and mechanistic targeting of rapamycin signaling, obtaining an important role in a number of pathological events such as the one generated by the recent pandemic. Both new and previous work in humans and mice provide a strong rationale for further examining the role of klotho in health and aging. KEY WORDS: Proteins, Aging, Inflammation, Reactive Oxygen Species, Diseaseen-US
dc.descriptionKlotho es una proteína transmembrana de un solo paso que consta de 1012 aminoácidos  y se expresa fuerte y débilmente en células epiteliales renales tubulares distales y proximales, respectivamente. Hay cuatro grupos de proteínas Klotho. El gen α Klotho se expresa abundantemente en riñones, glándulas paratiroides, plexo coroideo, y también en la corteza cerebral, la médula espinal, cerebelo, hipotálamo, hipófisis, glándulas paratiroides, ovario,  testículos, células epiteliales del seno, placenta, páncreas, oído interno, vascular células del músculo liso o intestino. KLOTHO exhibe múltiples funciones, además de la excreción de fosfato, incluida la mejora del estrés oxidativo y la inhibición de vías de señalización del factor de crecimiento de insulina, Wnt / β-catenina, transformación del factor de crecimiento -β1, y el objetivo mecanicista de la señalización de rapamicina, obteniendo un importante papel dentro de un sin número de eventos patológicos como el que generó la reciente pandemia. Tanto nuevos trabajos como anteriores en humanos y los ratones proporcionan una fuerte justificación para examinar más a fondo el papel del klotho en la salud y el envejecimiento.  es-ES
dc.descriptionKlotho é uma proteína transmembrana de uma etapa que consiste em 1012 aminoácidos e é forte e fracamente expressa em células epiteliais renais tubulares distais e proximais, respectivamente. Existem quatro grupos de proteínas Klotho. O gene α Klotho é abundantemente expresso em rins, glândulas paratireóides, plexo coróide, bem como no córtex cerebral, medula espinhal, cerebelo, hipotálamo, glândulas pituitárias, ovário, testículos, células epiteliais do seio, placenta, pâncreas, ouvido interno, endotélio vascular do músculo liso e intestinal. Klotho apresenta múltiplas funções, além da excreção de fosfato, incluindo a melhora do estresse oxidativo e inibição das vias de sinalização do fator de crescimento insulínico, WNT/β-catenina, transformação do fator de crescimento-β1 e o objetivo mecanicista da sinalização da rapamicina, de modo que um papel importante dentro de inúmeros eventos patológicos, como o que causou a recente pandemia gerada pela covid-19. Estudos novos e anteriores em humanos e camundongos (por exemplo, o impacto do Klotho na lesão pulmonar aguda) fornecem uma forte justificativa para examinar melhor o papel do Klotho na saúde e no envelhecimento.pt-BR
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dc.languagespa
dc.publisherUniversidad Militar Nueva Granadaes-ES
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rmed/article/view/5021/5013
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rmed/article/view/5021/5071
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dc.rightsDerechos de autor 2021 Revista Medes-ES
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0es-ES
dc.sourceRevista Med; Vol. 29 No. 1 (2021): january - june; 25-35en-US
dc.sourceRevista Med; Vol. 29 Núm. 1 (2021): enero - junio; 25-35es-ES
dc.source1909-7700
dc.source0121-5256
dc.titleThe Great Role of Klothoen-US
dc.titleEl gran papel de Klothoes-ES
dc.titleO grande papel de Klothopt-BR
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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