Anti-nmda receptor encephalitis. Case Report and Literature Review

Encefalitis por anticuerpos contra el receptor de NMDA. Reporte de un caso y revisión de la literatura;
Encefalite causada por anticorpos contra o receptor nmda. Relatório de caso e revisão da literatura

dc.creatorForero, Edwin
dc.creatorCastro Vargas, Hernán
dc.date2020-07-01
dc.date.accessioned2022-12-15T18:29:11Z
dc.date.available2022-12-15T18:29:11Z
dc.identifierhttps://revistas.unimilitar.edu.co/index.php/rmed/article/view/4846
dc.identifier10.18359/rmed.4846
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5357492
dc.descriptionAnti-nmda receptor encephalitis is a severe, treatable, and potentially reversible disorder characterized by the presence of behavioral disturbances, seizures, and movement disorders. The presence of antibodies against the glutamate receptor (anti-nmda) in plasma or cerebrospinal fluid is specific to the diagnosis of the disease. Early recognition of the disease is vital for the patient’s prognosis since early management facilitates recovery and reduction of morbidity and mortality. Treatment consists of corticosteroids, intravenous immunoglobulin, or plasmapheresis as the first line of therapy, in addition to other immunomodulators, such as cyclophosphamide or rituximab, as the second line. Recovery is slow but improves as antibody titers decrease. Complete recovery occurs in up to 75 % of patients.en-US
dc.descriptionLa encefalitis por anticuerpos contra el receptor de nmda es un desorden grave, tratable y potencialmente reversible, caracterizado por la presencia de alteraciones en el comportamiento, convulsiones y trastornos del movimiento. La presencia de anticuerpos contra el receptor del glutamato (anti-nmda) en plasma o líquido cefalorraquídeo es específico para el diagnóstico de la enfermedad. El reconocimiento temprano de la enfermedad es vital para el pronóstico del paciente, dado que el manejo precoz facilita la recuperación y reducción de la morbimortalidad. El tratamiento consiste en la utilización de corticoides, inmunoglobulina intravenosa o plasmaféresis como primera línea de terapia; además de otros inmunomoduladores, como ciclofosfamida o rituximab, como segunda línea. La recuperación es lenta, pero presenta mejoría en la medida en que los títulos de anticuerpos disminuyen y llega a una recuperación completa hasta en 75 % de los pacientes.es-ES
dc.descriptionA encefalite causada por anticorpos contra o receptor nmda é um distúrbio grave, tratável e potencialmente reversível, caracterizado pela presença de alterações comportamentais, convulsões e transtornos de movimento. A presença de anticorpos contra o receptor de glutamato (anti-nmda) no plasma ou no líquido cefalorraquidiano é específica para o diagnóstico da doença. O reconhecimento precoce da doença é vital para o prognóstico do paciente, visto que o tratamento precoce facilita a recuperação e a redução da morbimortalidade. O tratamento consiste no uso de corticoides, imunoglobulina intravenosa ou plasmaférese como primeira linha de terapia. Além de outros imunomoduladores, como ciclofosfamida ou rituximabe, como segunda linha. A recuperação é lenta, mas apresenta melhora à medida que os títulos de anticorpos diminuem e a recuperação completa ocorre em até 75% dos pacientes.pt-BR
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dc.formatapplication/pdf
dc.languagespa
dc.publisherUniversidad Militar Nueva Granadaes-ES
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rmed/article/view/4846/3951
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rmed/article/view/4846/4118
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dc.rightsDerechos de autor 2020 Revista Medes-ES
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0es-ES
dc.sourceRevista Med; Vol. 27 No. 2 (2019): july - december; 113-120en-US
dc.sourceRevista Med; Vol. 27 Núm. 2 (2019): julio - diciembre; 113-120es-ES
dc.source1909-7700
dc.source0121-5256
dc.titleAnti-nmda receptor encephalitis. Case Report and Literature Reviewen-US
dc.titleEncefalitis por anticuerpos contra el receptor de NMDA. Reporte de un caso y revisión de la literaturaes-ES
dc.titleEncefalite causada por anticorpos contra o receptor nmda. Relatório de caso e revisão da literaturapt-BR
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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