Transplant autologous “enhanced” stem cells CD34+ bone marrow in patients with refractory angina

Trasplante autólogo “potenciado”, de células madre CD34+ de médula ósea, en pacientes con angina refractaria. Estudio piloto;
Transplante autólogo “melhorado” stem cells medula óssea cd34+ em pacientes com angina refratária: estudo piloto

dc.creatorBlanco, Margarita I.
dc.creatorOliveros, Henry
dc.creatorBenjamín, Ospino
dc.creatorÁlvarez, Oscar
dc.creatorVásquez, Juan Felipe
dc.creatorÁvila, Jenniffer P.
dc.creatorÁvila Portillo, Luz Mabel
dc.date2016-06-16
dc.date.accessioned2022-12-15T18:28:18Z
dc.date.available2022-12-15T18:28:18Z
dc.identifierhttps://revistas.unimilitar.edu.co/index.php/rmed/article/view/2331
dc.identifier10.18359/rmed.2331
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5357402
dc.descriptionObjective: To evaluate the efficacy of 6 months of autologous CD34+ stem cells in bone marrow “enhanced” by ischemic preconditioning in patients with refractory angina.Methods: A pilot study with 14 patients with refractory angina, with a functional class greater than or equal to III clinical (NYHA and CCS), of the Department of Cardiology of the Central Military Hospital. They were selected by convenience 14 patients who were randomly assigned to two groups, the first (intervention) with autologous stem cells CD34+ bone marrow powered by ischemic preconditioning, intravenously more conventional medical treat­ment, and the second (control) with conventional medical treatment. Baseline measurements were performed and six months’ threshold angina/ischemia measured in mets and functional class.Results: Comparing the medians, the change in threshold value angina/ischemia six months later for the interven­tion group was 3.5 mets vs 0.9 mets for the control group P = 0.013. No inherent complications to treatment were recorded.Conclusions: In this study patients with refractory angina who underwent autologous stem cell transplant of bone marrow CD34+ powered by ischemic preconditioning, showed an improvement in threshold angina and functional class of 6 months.en-US
dc.descriptionObjetivo: Evaluar la eficacia a 6 meses del trasplante autólogo de células madre CD34+ de médula ósea “potenciado”, mediante pre-condicionamiento isquémico en pacientes con angina refractaria.Métodos: Estudio piloto con 14 pacientes con angina refractaria, clase funcional clínica mayor o igual a III (NYHA y CCS), del Servicio de Cardiología del Hospital Militar Central. Fueron seleccionados por conveniencia 14 pacientes los cuales se asignaron aleatoriamente a 2 grupos, el primero (intervención) con trasplante autólogo de células madre CD34+ de médula ósea potenciado mediante pre-condicionamiento isquémico por vía intravenosa más tratamiento médico convencional, y el segundo (control) con tratamiento médico convencional. Se realizaron mediciones basales a 6 meses del umbral de angina/isquemia medido en mets y clase funcional.Resultados: Al comparar las medianas, el cambio en el valor umbral de angina/isquemia 6 meses después, para el grupo intervenido fue de 3.5 mets vs 0.9 mets, para el grupo control P= 0.013. No se registraron complicaciones inherentes al tratamiento.Conclusiones: En esta investigación, los pacientes con angina refractaria intervenidos con trasplante autólogo de células madre de médula ósea CD34+ potenciado mediante precondicionamiento isquémico mostraron mejoría del umbral de angina y clase funcional a 6 meses. es-ES
dc.descriptionObjetivo: Avaliar a eficácia de 6 meses de células-tronco autólogas CD34 + na medula óssea “aumentada” pelo pré-condicionamento isquêmico em pacientes com angina refratária.Métodos: Um estudo piloto com 14 pacientes com angina refratária, com classe funcional maior ou igual a III clínica (NYHA e CCS), Do Departamento de Cardiologia do Hospital Militar Central. Eles foram selecionados por conveniência 14 pacientes que foram aleatoriamente designados para dois grupos, a primeira (intervenção) com cé­lulas-tronco autólogas CD34+ medula óssea alimentado por pré-condicionamento isquêmico, tratamento intravenoso mais convencional, e o segundo (controle) com tratamento médico convencional. Medidas de linha de base foram realizadas e seis meses de angina limiar /isquemia medido em mets e classe funcional.Resultados: Comparando as mediana, a alteração do valor limiar angina / isquemia seis meses depois para o grupo de intervenção foi de 3,5 mets vs 0,9 mets para o grupo de controlo P = 0,013. Não foram registadas complicações inerentes ao tratamento.Conclusões: Neste estudo, pacientes com angina refratária submetidos a transplante de células-tronco autólogas de medula óssea CD34+ alimentado por pré-condicionamento isquêmico, apresentaram melhora da angina limiar e classe funcional de 6 meses.pt-BR
dc.formatapplication/pdf
dc.languagespa
dc.publisherUniversidad Militar Nueva Granadaes-ES
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rmed/article/view/2331/2418
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dc.rightsDerechos de autor 2016 Revista Medes-ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0es-ES
dc.sourceRevista Med; Vol. 24 No. 1 (2016): january - june; 46-58en-US
dc.sourceRevista Med; Vol. 24 Núm. 1 (2016): enero - junio; 46-58es-ES
dc.source1909-7700
dc.source0121-5256
dc.subjectHematopoietic stem cellsen-US
dc.subjectangina pectorisen-US
dc.subjectischemic preconditioningen-US
dc.subjectCélulas madre hematopoyéticases-ES
dc.subjectAngina de pechoes-ES
dc.subjectprecondicionamiento isquémicoes-ES
dc.subjectCélulas-tronco hematopoéticaspt-BR
dc.subjectAngina de peitopt-BR
dc.subjectPré-condicionamento isquêmicopt-BR
dc.titleTransplant autologous “enhanced” stem cells CD34+ bone marrow in patients with refractory anginaen-US
dc.titleTrasplante autólogo “potenciado”, de células madre CD34+ de médula ósea, en pacientes con angina refractaria. Estudio pilotoes-ES
dc.titleTransplante autólogo “melhorado” stem cells medula óssea cd34+ em pacientes com angina refratária: estudo pilotopt-BR
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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