Asociación entre receptores de leptina en testículo, niveles de leptina y testosterona en terneros púberes

dc.creatorRuiz, Z.Tatiana
dc.creatorOlivera, Martha
dc.date2010-09-01
dc.date.accessioned2022-12-15T14:41:31Z
dc.date.available2022-12-15T14:41:31Z
dc.identifierhttps://revistamvz.unicordoba.edu.co/article/view/307
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5352865
dc.descriptionObjetivos. Describir la presencia de receptores de leptina (OBR) en el testículo en la llegada de la pubertad en terneros y estudiar la posible asociación entre la expresión de éstos y los niveles de leptina (L) y de testosterona. Materiales y métodos. Se utilizaron 6 terneros Holstein x Cebú a los cuales se les midió quincenalmente y durante 7 meses concentraciones de testosterona y de L por RIA. Fueron castrados unilateralmente según períodos peripuberales para estudiar por RT-PCR la expresión de isoformas del receptor de L. El análisis estadístico se realizó con el programa Statistica®. Resultados. La testosterona presentó niveles desde menores a 1ng/mL a los 6 y 6.5 meses de edad, hasta concentraciones de 5.3 ng/ml a los 12.5 meses antes de la llegada a pubertad, momento en el cual los animales tuvieron niveles de 4.01±1.8 ng/ml. Las concentraciones de L variaron entre 0.61 y 0.98 ng/ml, con una concentración en pubertad de 0.91±0.05 ng/ml. Dos isoformas, OBRi y OBRb, fueron encontradas y se correlacionaron significativamente entre ellas en la pubertad. Se hallaron correlaciones negativas entre OBRi-OBRb y niveles de testosterona y de L (p=0.08). Los niveles de testosterona y de L mostraron una correlación directa significativa. Conclusiones. Se sugiere un posible efecto directo de la leptina en gónadas de terneros hasta la llegada a pubertad. La correlación entre las isoformas de OBR y su asociación con las concentraciones de leptina y testosterona también sugiere la acción complementaria o conjunta de ambos receptores OBR en testículos de terneros peripuberales.es-ES
dc.formatapplication/pdf
dc.languagespa
dc.publisherUniversidad de Córdobaes-ES
dc.relationhttps://revistamvz.unicordoba.edu.co/article/view/307/375
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dc.sourceJournal MVZ Cordoba; Vol. 15 No. 3 (2010): Revista MVZ Córdoba volumen 15(3) Septiembre-Diciembre 2010en-US
dc.sourceRevista MVZ Córdoba; Vol. 15 Núm. 3 (2010): Revista MVZ Córdoba volumen 15(3) Septiembre-Diciembre 2010es-ES
dc.source1909-0544
dc.source0122-0268
dc.subjectObesity genees-ES
dc.subjecthormonees-ES
dc.subjectmale sexual maturationes-ES
dc.titleAsociación entre receptores de leptina en testículo, niveles de leptina y testosterona en terneros púbereses-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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