Morphological alterations in skeletal muscle of spontaneously hyperensive rats

dc.creatorHernández, Noelina
dc.creatorTorres, Sonia H.
dc.creatorLosada, Mercedes
dc.creatorFinol, Héctor J.
dc.date2013-06-12
dc.date.accessioned2022-11-05T00:54:14Z
dc.date.available2022-11-05T00:54:14Z
dc.identifierhttps://produccioncientificaluz.org/index.php/investigacion/article/view/28686
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5135729
dc.description  The Extensor digitorum longus (EDL) and the soleus museles of spontaneously hypetensive rats (SHR) were studied in comparison with those of their normal counterparts, the Wistar Kyoto (WKY) rats. Quantitative assessment of capillaries and fibre typing was done with optical microscopy, while the study of capillary abnormalities was performed by ultrastructural observation. There were no differences in fibre type proportion or in capillarity indexes between the SHR and the control rats. A reduction in the area of IIB fibres was found in the EDL muscle of the hypertensive animals. The ultrastructural study showed abnormalities in the capillaries of both muscles in SHR, the cross section of the endothelial cells was enlarged; there was irregular distribution of caveolae and pinocytic vesicles, the capillary base ment membrane showed irregular width, with parts en grossed and reduplicated. Some pericytes were prominent. There were macrophages present in the interstitial space. In some muscle fibres there was disorganization of the sarcomere structure, swelling of the sarcotubular system, abundant autophagic vacuoles, and proliferative satellite cells. There were abundant collagen fibrils. The presence of cellular rests, autophagic vacuoles and loss of sarcolemma indicated necrosis. It can be concluded, that in SHR, muscle capillaries showed alterations that may be the substrate of functional rarefaction, although anatomical rarefaction (number reduction) could not bedemon strated. In EDL and soleus muscles of SHR, signs of a mild myopathy with focal fibrosis were present.es-ES
dc.formatapplication/pdf
dc.languagespa
dc.publisherUniversidad del Zuliaes-ES
dc.relationhttps://produccioncientificaluz.org/index.php/investigacion/article/view/28686/29401
dc.rightsDerechos de autor 2016 Investigación Clínicaes-ES
dc.sourceInvestigación Clínica; Vol. 49 Núm. 1es-ES
dc.source2477-9393
dc.source0535-5133
dc.subjectSkele al musclees-ES
dc.subjectmuscle capillarieses-ES
dc.subjecthistochemistryes-ES
dc.subjectultrastructurees-ES
dc.subjectfibrosises-ES
dc.titleMorphological alterations in skeletal muscle of spontaneously hyperensive ratses-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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