dc.contributor | Bologna Molina Ronell, Research Department, School of Dentistry, Universidad Juárez del Estado de Durango (UJED), Durango, México .School of Dentistry, Universidad de la República (UDELAR). Montevideo, Uruguay | |
dc.contributor | Mosqueda Taylor Adalberto, Health Care Department, Universidad Autónoma Metropolitana, Xochimilco. Mexico | |
dc.contributor | Molina Frechero Nelly, Health Care Department, Universidad Autónoma Metropolitana, Xochimilco. Mexico | |
dc.contributor | Mori Estevez Ana Dolores, Pathology Department , Hospital Universitario “Gral. Calixto García” La Havana, Cuba | |
dc.contributor | Sánchez Acuña Guillermo, Maxillofacial Department, Hospital Universitario “Gral. Calixto García” La Havana, Cuba | |
dc.creator | Bologna Molina, Ronell | |
dc.creator | Mosqueda Taylor, Adalberto | |
dc.creator | Molina Frechero, Nelly | |
dc.creator | Mori Estevez, Ana Dolores | |
dc.creator | Sánchez Acuña, Guillermo | |
dc.date.accessioned | 2022-05-06T15:31:43Z | |
dc.date.accessioned | 2022-10-28T20:22:03Z | |
dc.date.available | 2022-05-06T15:31:43Z | |
dc.date.available | 2022-10-28T20:22:03Z | |
dc.date.created | 2022-05-06T15:31:43Z | |
dc.date.issued | 2013 | |
dc.identifier | Bologna Molina, R, Mosqueda Taylor, A, Molina Frechero, N.y otros. "Comparison of the value of PCNA and Ki-67 as markers of cell proliferation in ameloblastic tumors"Med Oral Patol Oral Cir Bucal. 2013 Mar 1;18 (2):e174-9. [en línea] 2013. doi:10.4317/medoral.18573 | |
dc.identifier | https://hdl.handle.net/20.500.12008/31502 | |
dc.identifier | doi:10.4317/medoral.18573 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4985418 | |
dc.description.abstract | The aim of this study was to compare among PCNAand Ki-67 as the most reliable immunohistochemical
marker for evaluating cell proliferation in ameloblastic tumors. Study design: Observational, retrospective, and descriptive study of a large series of ameloblastic tumors, composed of 161 ameloblastomas and four ameloblastic carcinomas, to determine and compare PCNA and Ki-67 expression using immunohistochemistry techniques. Results: When analyzing Ki-67 positivity, the desmoplastic ameloblastoma demonstrated a significantly lower proliferation rate (1.9%) compared with the solid/multicystic and unicystic ameloblastomas and ameloblastic carcinomas (p<0.05), whereas the ameloblastic carcinomas displayed a significantly higher rate compared with all of the other ameloblastomas (48.7%) (p<0.05). When analyzing cell proliferation with PCNA, we found significant differences only between the ameloblastic carcinomas (93.3%) and the desmoplastic ameloblastomas (p<0.05). When differences between the immunopositivity for PCNA and Ki-67 were compared, the percentages were higher for PCNA in all types of ameloblastomas and ameloblastic carcinomas. In all cases, the percentages were greater than 80%, whereas the immunopositivity for Ki-67 was significantly lower; for example, the ameloblastic carcinoma expressed the highest positivity and only reached 48.7%, compared to 93.3% when we used PCNA. Conclusions: In the present study, when we used the proliferation cell marker Ki-67, the percentages of positivity were more specific and varied among the different types of ameloblastomas, suggesting that Ki-67 is a more specific marker for the proliferation of ameloblastic tumor cells. | |
dc.language | en | |
dc.relation | Med Oral Patol Oral Cir Bucal. 2013 Mar 1;18 (2):e174-9. | |
dc.rights | Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0) | |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | |
dc.subject | Ameloblastomas | |
dc.subject | Ameloblastic carcinoma | |
dc.subject | PCNA | |
dc.subject | Ki-67 | |
dc.subject | Cell proliferation markers | |
dc.title | Comparison of the value of PCNA and Ki-67 as markers of cell proliferation in ameloblastic tumors | |
dc.type | Artículo | |