dc.contributorBologna Molina Ronell, Research Department, School of Dentistry, Universidad Juárez del Estado de Durango (UJED), Durango, México .School of Dentistry, Universidad de la República (UDELAR). Montevideo, Uruguay
dc.contributorMosqueda Taylor Adalberto, Health Care Department, Universidad Autónoma Metropolitana, Xochimilco. Mexico
dc.contributorMolina Frechero Nelly, Health Care Department, Universidad Autónoma Metropolitana, Xochimilco. Mexico
dc.contributorMori Estevez Ana Dolores, Pathology Department , Hospital Universitario “Gral. Calixto García” La Havana, Cuba
dc.contributorSánchez Acuña Guillermo, Maxillofacial Department, Hospital Universitario “Gral. Calixto García” La Havana, Cuba
dc.creatorBologna Molina, Ronell
dc.creatorMosqueda Taylor, Adalberto
dc.creatorMolina Frechero, Nelly
dc.creatorMori Estevez, Ana Dolores
dc.creatorSánchez Acuña, Guillermo
dc.date.accessioned2022-05-06T15:31:43Z
dc.date.accessioned2022-10-28T20:22:03Z
dc.date.available2022-05-06T15:31:43Z
dc.date.available2022-10-28T20:22:03Z
dc.date.created2022-05-06T15:31:43Z
dc.date.issued2013
dc.identifierBologna Molina, R, Mosqueda Taylor, A, Molina Frechero, N.y otros. "Comparison of the value of PCNA and Ki-67 as markers of cell proliferation in ameloblastic tumors"Med Oral Patol Oral Cir Bucal. 2013 Mar 1;18 (2):e174-9. [en línea] 2013. doi:10.4317/medoral.18573
dc.identifierhttps://hdl.handle.net/20.500.12008/31502
dc.identifierdoi:10.4317/medoral.18573
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4985418
dc.description.abstractThe aim of this study was to compare among PCNAand Ki-67 as the most reliable immunohistochemical marker for evaluating cell proliferation in ameloblastic tumors. Study design: Observational, retrospective, and descriptive study of a large series of ameloblastic tumors, composed of 161 ameloblastomas and four ameloblastic carcinomas, to determine and compare PCNA and Ki-67 expression using immunohistochemistry techniques. Results: When analyzing Ki-67 positivity, the desmoplastic ameloblastoma demonstrated a significantly lower proliferation rate (1.9%) compared with the solid/multicystic and unicystic ameloblastomas and ameloblastic carcinomas (p<0.05), whereas the ameloblastic carcinomas displayed a significantly higher rate compared with all of the other ameloblastomas (48.7%) (p<0.05). When analyzing cell proliferation with PCNA, we found significant differences only between the ameloblastic carcinomas (93.3%) and the desmoplastic ameloblastomas (p<0.05). When differences between the immunopositivity for PCNA and Ki-67 were compared, the percentages were higher for PCNA in all types of ameloblastomas and ameloblastic carcinomas. In all cases, the percentages were greater than 80%, whereas the immunopositivity for Ki-67 was significantly lower; for example, the ameloblastic carcinoma expressed the highest positivity and only reached 48.7%, compared to 93.3% when we used PCNA. Conclusions: In the present study, when we used the proliferation cell marker Ki-67, the percentages of positivity were more specific and varied among the different types of ameloblastomas, suggesting that Ki-67 is a more specific marker for the proliferation of ameloblastic tumor cells.
dc.languageen
dc.relationMed Oral Patol Oral Cir Bucal. 2013 Mar 1;18 (2):e174-9.
dc.rightsLicencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0)
dc.rightsLas obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)
dc.subjectAmeloblastomas
dc.subjectAmeloblastic carcinoma
dc.subjectPCNA
dc.subjectKi-67
dc.subjectCell proliferation markers
dc.titleComparison of the value of PCNA and Ki-67 as markers of cell proliferation in ameloblastic tumors
dc.typeArtículo


Este ítem pertenece a la siguiente institución