Regulatory Interaction between Calmodulin and the Epidermal Growth Factor Receptor

dc.creatorBENGURÍA, ALBERTO
dc.creatorMARTIN-NIETO, JOSÉ
dc.creatorBENAÍM, GUSTAVO
dc.creatorVILLALOBO, ANTONIO
dc.date2017-04-05T16:23:56Z
dc.date2017-04-05T16:23:56Z
dc.date1995
dc.date.accessioned2022-10-28T01:24:19Z
dc.date.available2022-10-28T01:24:19Z
dc.identifierDOI: 10.1111/j.1749-6632.1995.tb26698.x
dc.identifierhttp://hdl.handle.net/10872/15632
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4949194
dc.descriptionGrowth factor-stimulated cell proliferation is preceded by a transient increase in the cytoplasmic Ca2+ concentration, and calmodulin, an intracellular calcium receptor protein, appears to intervene in the modulation of this process. Calmodulin binds to nuclear proteins and could therefore affect their functions However, calmodulin does not control cell proliferation by acting exclusively at the nuclear level. Several lines of evidence obtained in our laboratory indicate that the epidermal growth factor receptor (EGFR) is a calmodulin-binding protein and that calmodulin acts as a modulator of its intrinsic tyrosine kinase activity.
dc.descriptionInstituto de Investigaciones Biomédicas Consejo Superior de Investigaciones Científicas Arturo Duperier 4 28029 Madrid, Spain. Centro de Biología Celular Facultad de Ciencias Universidad Central de Venezuela Caracas, Venezuela
dc.languageen
dc.publisherANNALS NEW YORK ACADEMY OF SCIENCES
dc.subjectGrowth factor-stimulated cell
dc.subjectcell proliferation
dc.subjectcytoplasmic
dc.subjectcalmodulin
dc.subjectreceptor protein
dc.subjectintracellular calcium
dc.titleRegulatory Interaction between Calmodulin and the Epidermal Growth Factor Receptor
dc.typeArticle


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