| dc.creator | Muller, Grete Y. | |
| dc.creator | Zabaleta, Mercedes E. | |
| dc.creator | Arminio, Anabella | |
| dc.creator | Colmenares, Carmen J. | |
| dc.creator | Capriles, Freya I. | |
| dc.creator | Bianco Colmenares, Nicolás E. | |
| dc.creator | Machado, Irma V. | |
| dc.date | 2017-02-17T17:14:47Z | |
| dc.date | 2017-02-17T17:14:47Z | |
| dc.date | 1992-04 | |
| dc.date.accessioned | 2022-10-28T01:21:19Z | |
| dc.date.available | 2022-10-28T01:21:19Z | |
| dc.identifier | 0085-2538 | |
| dc.identifier | http://hdl.handle.net/10872/14508 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4948128 | |
| dc.description | Risk factors for dialysis-associated hepatitis C in Venezuela. Utilizing the first and second generation of enzyme immunoassays which detect antibodies to the C virus we investigated the frequency of anti-HCV antibodies in 315 patients undergoing hemodialysis. Other subpopulations at risk were used as reference groups. One hundred and twenty-three samples (39%) from the hemodialysis group repeatedly showed anti-HCV positive antibodies while only 19% and 1% were positive in the reference groups. The rate of anti-HCV reactive patients correlated with time on hemodialysis (< 1 year, 17% 1 to 5 years 43% > 5 years, 64% r = 0.94, P < 0.001) and with the number of blood transfusions (1 to 10, 40% > 10, 76% r = 0.97; P < 0.001). Length of time on hemodialysis was shown to be the major risk factor in thirty-three anti-HCV positive patients who had no previous record of blood transfusions. Co-infection with HBV was demonstrated in 41% out of 123 anti-HCV reactive patients, and increased alanine aminotransferase (ALT) activity was documented in this co-infected group. Our results further extend the observations on the predisposing factors to HCV spread in hemodialysis units, and suggest that in these renal patients co-infection with C and B viruses is a major cause of rising ALT activity. | |
| dc.language | en | |
| dc.publisher | Kidney lnternational | |
| dc.relation | Vol. 41;No. 4 pp 1055-1058 | |
| dc.subject | Risk factors | |
| dc.subject | hepatitis C | |
| dc.subject | dialysis | |
| dc.subject | enzyme immunoassays | |
| dc.subject | C virus | |
| dc.subject | hemodialysis | |
| dc.title | Risk factors for dialysis-associated hepatitis e in Venezuela | |
| dc.type | Article | |
