Intracellular topography of immunoreactlve gastrin demonstrated using electron immunocytochemistry.
| dc.creator | Varndell, I.M. | |
| dc.creator | Harris, A. | |
| dc.creator | Tapia, Félix J. | |
| dc.creator | Yanaihara, N. | |
| dc.creator | De Mey, J. | |
| dc.creator | Bloom, S.R | |
| dc.creator | Polak, J.M. | |
| dc.date | 2016-04-07T23:14:19Z | |
| dc.date | 2016-04-07T23:14:19Z | |
| dc.date | 1983-07 | |
| dc.date.accessioned | 2022-10-28T01:19:37Z | |
| dc.date.available | 2022-10-28T01:19:37Z | |
| dc.identifier | 0014-4754 | |
| dc.identifier | http://hdl.handle.net/10872/13853 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4947498 | |
| dc.description | Gastrin (G )-producing cells from the mammalian gastric antrum have been investigated using computer-assisted morphometry and a novel double colloidal gold-labeled-immunoglobulin electron immunocytochemical procedure. Correlation analysis of human antral G-cells indica tes (p < 0.001) that a single population of granules exists with small (160 nm) electron-dense and large (240 nm) electron-lucent forms representing the extremes. Non-crossreacting region-specific antisera have been used to visualize G-17 and G34 (progastrin) to the small electron-dense granules and G-17 lo the other intermediate forms. From the results we propose a topographic segregation of immunoreactive gastrins within 2 apparently distinct granule subclasses and suggest that this may represent the pathway of granule maturation. | |
| dc.language | en | |
| dc.publisher | Experientia | |
| dc.relation | Vol. 15;Nº 39 | |
| dc.subject | Gastrin (G ) | |
| dc.subject | producing cells | |
| dc.subject | assisted morphometry | |
| dc.subject | electron-dense | |
| dc.subject | electron-lucent | |
| dc.title | Intracellular topography of immunoreactlve gastrin demonstrated using electron immunocytochemistry. | |
| dc.type | Article |