LEUKOCYTE SUBSETS IN THE GRANULOMATOUS RESPONSE PRODUCED AFTER INOCULATION WITH MYCOBACTERIUM LEPR 4E BCG IN LEPROMATOUS PATIENTS

dc.creatorGross, Ana
dc.creatorWeiss, Eduardo
dc.creatorTapia, Félix J.
dc.creatorAranzazu, Nacarid
dc.creatorGallinoto, María E.
dc.creatorConvit, Jacinto
dc.date2016-01-26T00:37:29Z
dc.date2016-01-26T00:37:29Z
dc.date1988
dc.date.accessioned2022-10-28T01:17:57Z
dc.date.available2022-10-28T01:17:57Z
dc.identifier0002-9637
dc.identifierhttp://hdl.handle.net/10872/13208
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4946873
dc.descriptionLeukocyte subsets present in the granulomatous response produced after the inoculation of a mixture of Mycobacterium leprae and BCG in lepromatous leprosy patients Were Characterized in situ using monoclonal antibodies and an immunoperoxidase technique. The granuloma produced after M. leprae -BCG Showed a distribution like pattern to tuberculoid granulomas . T lymphocytes bearing the CD8 phenotype (T cytotoxic / suppressor) Were sequestered to the periphery of the epithelioid tubercles and T helper-inducer CD4 + lymphocytes infiltrate the Were distributed THROUGHOUT. Langerhans cells CD1 + Were Increased in the epidermis, dermis and in They Were localized mainly in the mantle surrounding the granuloma . Most of the dermal infiltrate produced after the inoculation or M. leprae -BCG expresses the HLA antigen -DR. Similarly, keratinocytes Were MOST Also positive to this MHC antigen. The granulomatous response to BCG was similar to the inoculation of a mixture of M. leprae -BCG, however acid-fast bacilla Were still present. The inoculation of M. leprae produced by macrophage granuloma With No clearing of the bacilla Which Resembles the lepromatous leprosy granuloma.
dc.languageen
dc.publisherThe American Journal of Tropical Medicine and Hygiene
dc.relationVol. 38;Nº 3
dc.subjectLeukocyte subsets
dc.subjectgranulomatous
dc.subjectMycobacterium leprae
dc.subjectlepromatous leprosy patients
dc.subjectmonoclonal antibodies
dc.subjectimmunoperoxidase technique
dc.titleLEUKOCYTE SUBSETS IN THE GRANULOMATOUS RESPONSE PRODUCED AFTER INOCULATION WITH MYCOBACTERIUM LEPR 4E BCG IN LEPROMATOUS PATIENTS
dc.typeArticle


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