| dc.creator | Hagel, Isabel | |
| dc.creator | Cabrera, Maira | |
| dc.creator | Buvat, Erika | |
| dc.creator | Gutierrez, Loana | |
| dc.creator | Santaella, Carlos | |
| dc.creator | Borges, Rafael | |
| dc.creator | Infante, Benito | |
| dc.creator | Salas, Carolina | |
| dc.creator | Barrios, Yelitza | |
| dc.date | 2014-02-07T11:45:35Z | |
| dc.date | 2014-02-07T11:45:35Z | |
| dc.date | 2008-05-03 | |
| dc.date.accessioned | 2022-10-28T00:57:19Z | |
| dc.date.available | 2022-10-28T00:57:19Z | |
| dc.identifier | J Trop pediatr | |
| dc.identifier | 0142-6338 | |
| dc.identifier | http://hdl.handle.net/10872/5634 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4939780 | |
| dc.description | We studied the production of anti
parasite antibodies and the resistance
against A. lumbricoides infection among
the school population of three different
Venezuelan ethnic groups: Warao
Amerindians, Afro- Americans and white
‘Creole’ descendents. The prevalence and
intensity of A. lumbricoides were determined
before and after 1 year of anthelminthic
treatment. Parasitic loads were
associated to pre-treatment serum levels of
anti A. lumbricoides IgE and IgG4 antibodies.
The intensity of the infection and
the proportion of re-infected children were
significantly lower (p<0.0001) among the
Warao Amerindians, exhibiting higher
levels of IgE (p<0.0001) and lower levels
of IgG4 (p<0.0001) compared to their
non-Amerindian counterparts. IgE levels
correlated inversely with the proportion
of re-infected children, whereas the levels
of IgG4 were positively associated. These
results suggest that ethnicity may influence
the balance of IgE/IgG4 levels, modulating
the intensity of A. lumbricoides and the
resistance to the infection. | |
| dc.description | En este trabajo se demuestra que diferencias en la produccion de anticuerpos especificos frente a Ascaris lumbricoides entre la poblacion infantil de diferentes grupos etnicos de venezuela difieren se relacionan con diferencias en la resistencia frente a la infeccion. | |
| dc.description | FONACIT | |
| dc.language | en | |
| dc.publisher | Journal Tropical Pediatrics | |
| dc.relation | vol 54;5 | |
| dc.subject | IgE IgG4 Amerindians | |
| dc.title | Antibody Responses and Resistance against Ascaris lumbricoides Infection among Venezuelan Rural Children: The Influence of Ethnicity | |
| dc.type | Article | |
