| dc.creator | Hagel, Isabel | |
| dc.creator | Puccio, Franca | |
| dc.creator | Lopez, Elianska | |
| dc.creator | Lugo, Dennis | |
| dc.creator | Cabrera, Maira | |
| dc.creator | Di Prisco, María Crístina | |
| dc.date | 2014-02-06T23:09:21Z | |
| dc.date | 2014-02-06T23:09:21Z | |
| dc.date | 2014-01-06 | |
| dc.date.accessioned | 2022-10-28T00:57:18Z | |
| dc.date.available | 2022-10-28T00:57:18Z | |
| dc.identifier | pediatr Allergy Immunol | |
| dc.identifier | 1399-3038 | |
| dc.identifier | http://hdl.handle.net/10872/5630 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4939777 | |
| dc.description | Background: We evaluated the influence of intestinal parasitic infection on food
sensitization associated to the severity of Atopic Dermatitis (AD) in a group of Warao
Amerindian pre- school children.
Methods: Feces examinations were performed in fresh stool specimens. Diagnosis of
AD was done according to Hannifin and Rajka criteria and SCORAD index. Skin
prick tests (SPT) were performed using extracts of cow’s milk (CM), hen’s egg (HE),
Dermatophagoides pteronyssinus and Dermatophagoides farinae . Serum CM and
HE-IgE levels (ELISA) were measured. Quantikine (R&D systems) assays were used
for the determination of IL-13, TNF-a IL-6, and sCD23 in supernatants of CM- and
HE- whole blood stimulated samples.
Results: Atopic Dermatitis was reported in 23% of the children. It was significantly
(p < 0.0001) associated toward both CM and HE- SPT positivity (p < 0.001). Giardia
duodenalis infection (37%) was associated to the presence of AD (p = 0.005) and to a
significant increase in the levels of CM stimulated TNF-a (p ¼ 0:006), IL-13
(p = 0.01), sCD23 (p = 0.001), CM-IgE (p = 0.012) and CM-SPT (p < 0.0001).
Similarly, G. duodenalis infection was particularly associated with the increase on
the levels of HE-stimulated TNF-a (p = 0.001), sCD23 (p = 0.001), HE-IgE levels
(p = 0.002) and HE-SPT (p = 0.001).
Conclusion: Gut inflammation caused by G. duodenalis may enhance food allergic
reactivity contributing to the manifestation of AD in these children. However, other
environmental factors (not considered in this work) as well as an atopic background
among the Warao population would also contribute to the presence of AD. | |
| dc.description | Este trabajo establece la influencia de la reactividad alergica frente a alimentos como leche y huevo asi como de la presencia de factores inmunologicos pro-inflamatorios tipo TH2 sobre la elevada prevalencia de dermatitis atopica encontrada en a poblacion infantil de la etnia Warao | |
| dc.description | PG-097946-2010/II CDCH, project. | |
| dc.language | en | |
| dc.publisher | Pediatric Allergy and Immunology | |
| dc.relation | DOI:10.1111/pai.12190;00 | |
| dc.subject | atopic dermatitis; food allergy; Giardia duodenalis; IgE; IL13; IL-6; TNF-a | |
| dc.title | Do intestinal parasites enhance food allergy and atopic dermatitis?: A study in Warao Amerindian children | |
| dc.type | Article | |
