| dc.creator | Galán, Jacob A | |
| dc.creator | Sánchez, Elda E | |
| dc.creator | Rodríguez-Acosta, Alexis | |
| dc.creator | Soto, Julio G | |
| dc.creator | Bashir, Sajid | |
| dc.creator | McLane, Mary Ann | |
| dc.creator | Paquette-Straub, Carrie | |
| dc.creator | Pérez, John C | |
| dc.date | 2013-11-28T15:50:46Z | |
| dc.date | 2013-11-28T15:50:46Z | |
| dc.date | 2013-11-28 | |
| dc.date.accessioned | 2022-10-28T00:56:24Z | |
| dc.date.available | 2022-10-28T00:56:24Z | |
| dc.identifier | http://hdl.handle.net/10872/5127 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4939349 | |
| dc.description | Disintegrins are low molecular weight proteins (4-15 kDa) with an RGD binding region
at their binding loop. Disintegrin and disintegrin-like proteins are found in the venom of four
families of snakes: Atractaspididae, Elapidae, Viperidae and Colubridae. This report describes
the biological activity of a disintegrin, crotatroxin 2, isolated by a three-step chromatography
procedure from the venom of the Western diamondback rattlesnake (Crotalus atrox). The intact
molecular mass for crotatroxin 2 was 7.384 kDa and 71 amino acids. Crotatroxin 2 inhibited
human whole blood platelet aggregation with an IC50 of 17.5 nM, inhibited cell (66.3p) migration
by 63%, and inhibited experimental lung tumor colonization in BALB/c mice at 1000 μg/kg. Our
data suggest that while crotatroxin 2 inhibits platelet aggregation, cancer cell migration, and lung
tumor colonization it is done via different integrins | |
| dc.description | Research Group (CBRG), Department of Chemistry, Texas A&M University-Kingsville,
FONACIT (G-2005000400), Caracas,Venezuela, and grant # CA098056 (MAM), University of
Delaware. | |
| dc.language | en_US | |
| dc.relation | Toxicon;51(7):1186-1196. (2008). | |
| dc.subject | lung tumor colonization | |
| dc.subject | cell migration, | |
| dc.subject | Crotalus atrox | |
| dc.subject | crotatroxin | |
| dc.subject | disintegrins | |
| dc.subject | venom | |
| dc.title | Inhibition of Lung Tumor Colonization and Cell Migration with the Disintegrin Crotatroxin 2 Isolated from the Venom of Crotalus atrox | |
| dc.type | Article | |
