Sodium-Calcium Exchanger Modulates the L-Glutamate Ca i 2+ Signalling in Type-1 Cerebellar Astrocytes

dc.creatorRojas, H
dc.creatorColina, C
dc.creatorRamos, M
dc.creatorBenaím, Gustavo
dc.creatorJaffe, E
dc.creatorCaputo, C
dc.creatorDi Polo, R
dc.date2013-10-25T16:33:23Z
dc.date2013-10-25T16:33:23Z
dc.date2013
dc.date.accessioned2022-10-28T00:55:30Z
dc.date.available2022-10-28T00:55:30Z
dc.identifierAvances en Medicina Experimental y Biología 961
dc.identifierDOI 10.1007/978-1-4614-4756-6_22,
dc.identifierhttp://hdl.handle.net/10872/4634
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4938916
dc.descriptionWe have previously demonstrated that rat type-1 cerebellar astrocytes express a very active Na + /Ca 2+ exchanger which accounts for most of the total plasma membrane Ca 2+ fl uxes and for the clearance of Ca i 2+ induced by physiological agonist. In this chapter, we have explored the mechanism by which the reverse Na + /Ca 2+ exchange is involved in agonistinduced Ca 2+ signalling in rat cerebellar astrocytes. Laser-scanning confocal microscopy experiments using immuno fl uorescence labelling of Na + /Ca 2+ exchanger and RyRs demonstrated that they are highly co-localized. The most important fi nding presented in this chapter is that L -glutamate activates the reverse mode of the Na + /Ca 2+ exchange by inducing a Na + entry through the electrogenic Na + -glutamate co-transporter and not through the ionophoric L -glutamate receptors as con fi rmed by pharmacological experiments with speci fi c blockers of ionophoric L -glutamate receptors, electrogenic glutamate transporters and the Na/Ca exchange.
dc.languageen
dc.publisherExperimental Medicine and Biology
dc.subjectNa + /Ca 2+ exchange
dc.subjectCICR
dc.subjectGlutamate
dc.subjectGlutamate transporter
dc.titleSodium-Calcium Exchanger Modulates the L-Glutamate Ca i 2+ Signalling in Type-1 Cerebellar Astrocytes
dc.typeArticle


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