| dc.creator | Niwa, MASAMI | |
| dc.creator | Israel, Anita | |
| dc.creator | Saavedra, Juan M. | |
| dc.date | 2011-06-20T20:28:49Z | |
| dc.date | 2011-06-20T20:28:49Z | |
| dc.date | 1985 | |
| dc.date.accessioned | 2022-10-28T00:47:27Z | |
| dc.date.available | 2022-10-28T00:47:27Z | |
| dc.identifier | http://hdl.handle.net/10872/171 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4935065 | |
| dc.description | The B-adrenoceptor antagonist pindolol, given p.o. (10 mg/kg, once a day for 7 days) to 4 and 24 week old male
spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), decreased plasma angiotensin-converting
enzyme (ACE) activity only in young SHR. Kinetic studies indicated that the treatmert ¡educed the ACE maximal
velocity or the numbe. of available ACE molecules. In vitro studies showed that pindolol had no direct effects on the
activity of plasma ACE. A decrease in soluble (loosely bound) ACE activity was observed in th€ lung of young SHR
treated with pindolol. The results suggest that pindolol affects the site of origin of plasma ACE. The susceptibility of
young SHR to pindolol may indicate a probable role of B-adrenocepto¡s i¡ the regulation of ACE activily in
spontaneous (genetic) hypertension. | |
| dc.language | en | |
| dc.publisher | European Journal ol Pharmocolog/, | |
| dc.relation | 110 (1985);133-136 | |
| dc.subject | Plasma angiotensin-converting enzyme | |
| dc.subject | Pindolol | |
| dc.subject | Spontaneouslyhypertensivera | |
| dc.subject | P-Adrenoceptors | |
| dc.title | PINDOLOL Df,CREASES PLASMA ANGIOTENSIN-CONVERTING ENZYME ACTIVITY IN YOUNG SPONTANEOUSLY HYPERTTNSIVE RATS | |
| dc.type | Article | |
