dc.date.accessioned2022-01-18T19:26:54Z
dc.date.available2022-01-18T19:26:54Z
dc.date.created2022-01-18T19:26:54Z
dc.date.issued2012
dc.identifierhttps://hdl.handle.net/20.500.12866/11001
dc.identifierhttps://doi.org/10.1136/bcr-2012-006574
dc.description.abstractResearch of human T lymphotropic virus type I (HTLV-1)-associated diseases is mostly focused on inflammatory and lymphoproliferative disorders. However, the immunosuppressive consequences of HTLV-1 infection are frequently ignored. In developing countries where exposure to parasitic and other tropical diseases is frequent, the burden of disease is significantly increased by opportunistic infections. Regulatory T cells (Tregs) are a CD4 T-cell subset capable of suppressing effector responses. During HTLV-1 infection, CD4+Foxp3+ cells are increased in HTLV-1-associated leukaemia/lymphoma (ATLL) as well as in non-leukaemic presentations. However, controversy exists regarding the actual regulatory function of these cells. In this report, we present two cases of HTLV-1 ATLL complicated by parasitic organisms and we provide a brief review of the literature regarding FoxP3+ regulatory T cells and their role as a possible mechanism for the immunosuppressive manifestations that take place during HTLV-1 infection.
dc.languageeng
dc.publisherBMJ Publishing Group
dc.relationBMJ Case Reports
dc.relation1757-790X
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectdisease association
dc.subjectcase report
dc.subjectcyclophosphamide
dc.subjectdiarrhea
dc.subjectflow cytometry
dc.subjectHuman T cell leukemia virus 1
dc.subjectskin biopsy
dc.subjectupregulation
dc.subjectstrongyloidiasis
dc.subjectprednisone
dc.subjectanemia
dc.subjectanamnesis
dc.subjectHuman T cell leukemia virus infection
dc.subjectivermectin
dc.subjectStrongyloides stercoralis
dc.subjectlamivudine
dc.subjectimmunohistochemistry
dc.subjectenzyme immunoassay
dc.subjectvirus identification
dc.subjectweight reduction
dc.subjectalpha interferon
dc.subjectaxillary lymph node
dc.subjectCD4+ T lymphocyte
dc.subjectcervical lymph node
dc.subjectdoxorubicin
dc.subjectepigastric pain
dc.subjectepithelium hyperplasia
dc.subjecterythroderma
dc.subjectgeneral condition deterioration
dc.subjecthospital acquired pneumonia
dc.subjectimmune deficiency
dc.subjectinguinal lymph node
dc.subjectlymphadenopathy
dc.subjectlymphocytosis
dc.subjectmicrocytic anemia
dc.subjectpruritus
dc.subjectregulatory T lymphocyte
dc.subjectSarcoptes scabiei
dc.subjectscabies
dc.subjectseptic shock
dc.subjectskin exfoliation
dc.subjectT cell leukemia
dc.subjecttenofovir
dc.subjecttinea
dc.subjecttranscription factor FOXP3
dc.subjectvincristine
dc.titleAre increased Foxp3+ regulatory T cells responsible for immunosuppression during HTLV-1 infection? Case reports and review of the literature
dc.typeinfo:eu-repo/semantics/review


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