dc.date.accessioned | 2022-01-18T19:26:54Z | |
dc.date.available | 2022-01-18T19:26:54Z | |
dc.date.created | 2022-01-18T19:26:54Z | |
dc.date.issued | 2012 | |
dc.identifier | https://hdl.handle.net/20.500.12866/11001 | |
dc.identifier | https://doi.org/10.1136/bcr-2012-006574 | |
dc.description.abstract | Research of human T lymphotropic virus type I (HTLV-1)-associated diseases is mostly focused on inflammatory and lymphoproliferative disorders. However, the immunosuppressive consequences of HTLV-1 infection are frequently ignored. In developing countries where exposure to parasitic and other tropical diseases is frequent, the burden of disease is significantly increased by opportunistic infections. Regulatory T cells (Tregs) are a CD4 T-cell subset capable of suppressing effector responses. During HTLV-1 infection, CD4+Foxp3+ cells are increased in HTLV-1-associated leukaemia/lymphoma (ATLL) as well as in non-leukaemic presentations. However, controversy exists regarding the actual regulatory function of these cells. In this report, we present two cases of HTLV-1 ATLL complicated by parasitic organisms and we provide a brief review of the literature regarding FoxP3+ regulatory T cells and their role as a possible mechanism for the immunosuppressive manifestations that take place during HTLV-1 infection. | |
dc.language | eng | |
dc.publisher | BMJ Publishing Group | |
dc.relation | BMJ Case Reports | |
dc.relation | 1757-790X | |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | disease association | |
dc.subject | case report | |
dc.subject | cyclophosphamide | |
dc.subject | diarrhea | |
dc.subject | flow cytometry | |
dc.subject | Human T cell leukemia virus 1 | |
dc.subject | skin biopsy | |
dc.subject | upregulation | |
dc.subject | strongyloidiasis | |
dc.subject | prednisone | |
dc.subject | anemia | |
dc.subject | anamnesis | |
dc.subject | Human T cell leukemia virus infection | |
dc.subject | ivermectin | |
dc.subject | Strongyloides stercoralis | |
dc.subject | lamivudine | |
dc.subject | immunohistochemistry | |
dc.subject | enzyme immunoassay | |
dc.subject | virus identification | |
dc.subject | weight reduction | |
dc.subject | alpha interferon | |
dc.subject | axillary lymph node | |
dc.subject | CD4+ T lymphocyte | |
dc.subject | cervical lymph node | |
dc.subject | doxorubicin | |
dc.subject | epigastric pain | |
dc.subject | epithelium hyperplasia | |
dc.subject | erythroderma | |
dc.subject | general condition deterioration | |
dc.subject | hospital acquired pneumonia | |
dc.subject | immune deficiency | |
dc.subject | inguinal lymph node | |
dc.subject | lymphadenopathy | |
dc.subject | lymphocytosis | |
dc.subject | microcytic anemia | |
dc.subject | pruritus | |
dc.subject | regulatory T lymphocyte | |
dc.subject | Sarcoptes scabiei | |
dc.subject | scabies | |
dc.subject | septic shock | |
dc.subject | skin exfoliation | |
dc.subject | T cell leukemia | |
dc.subject | tenofovir | |
dc.subject | tinea | |
dc.subject | transcription factor FOXP3 | |
dc.subject | vincristine | |
dc.title | Are increased Foxp3+ regulatory T cells responsible for immunosuppression during HTLV-1 infection? Case reports and review of the literature | |
dc.type | info:eu-repo/semantics/review | |