dc.date.accessioned2021-05-18T21:44:15Z
dc.date.available2021-05-18T21:44:15Z
dc.date.created2021-05-18T21:44:15Z
dc.date.issued2021
dc.identifierhttps://hdl.handle.net/20.500.12866/9375
dc.identifierhttps://doi.org/10.3389/fcimb.2021.607747
dc.description.abstractCampylobacter jejuni is the leading bacterial cause of gastroenteritis worldwide with excessive incidence in low-and middle-income countries (LMIC). During a survey for C. jejuni from putative animal hosts in a town in the Peruvian Amazon, we were able to isolate and whole genome sequence two C. jejuni strains from domesticated guinea pigs (Cavia porcellus). The C. jejuni isolated from guinea pigs had a novel multilocus sequence type that shared some alleles with other C. jejuni collected from guinea pigs. Average nucleotide identity and phylogenetic analysis with a collection of C. jejuni subsp. jejuni and C. jejuni subsp. doylei suggest that the guinea pig isolates are distinct. Genomic comparisons demonstrated gene gain and loss that could be associated with guinea pig host specialization related to guinea pig diet, anatomy, and physiology including the deletion of genes involved with selenium metabolism, including genes encoding the selenocysteine insertion machinery and selenocysteine-containing proteins
dc.languageeng
dc.publisherFrontiers Media
dc.relationFrontiers in Cellular and Infection Microbiology
dc.relation2235-2988
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectgastroenteritis
dc.subjectcampylobacteriosis
dc.subjectCampylobacter jejuni
dc.subjectselenocysteine
dc.subjectsource attribution
dc.titleGenomic Characterization of Campylobacter jejuni Adapted to the Guinea Pig (Cavia porcellus) Host
dc.typeinfo:eu-repo/semantics/article


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