Early sensory disturbances and seizures are common manifestations of familial Creutzfeldt-Jakob disease due to E200K PRNP mutation: Case report from two Peruvian families

dc.date.accessioned2021-05-18T21:44:15Z
dc.date.available2021-05-18T21:44:15Z
dc.date.created2021-05-18T21:44:15Z
dc.date.issued2021
dc.identifierhttps://hdl.handle.net/20.500.12866/9363
dc.identifierhttps://doi.org/10.1016/j.clineuro.2021.106490
dc.description.abstractHighlights: E200K-PRNP mutation is the most common cause of fCJD. The typical presentation includes rapidly progressive dementia, myoclonus, cerebellar manifestations, and other motor signs. Early sensory disturbances and seizures are infrequent symptoms. We described 4(out of 5) cases of fCJD manifesting ESD and seizures as dominant clinical features. The present findings further underline the clinical variability of fCJD
dc.languageeng
dc.publisherElsevier
dc.relationClinical Neurology and Neurosurgery
dc.relation1872-6968
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCreutzfeldt-Jakob disease
dc.subjectDementia
dc.subjectGenetics
dc.subjectSeizure
dc.subjectSensory disturbance
dc.titleEarly sensory disturbances and seizures are common manifestations of familial Creutzfeldt-Jakob disease due to E200K PRNP mutation: Case report from two Peruvian families
dc.typeinfo:eu-repo/semantics/article


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