| dc.date.accessioned | 2020-07-14T00:02:30Z | |
| dc.date.available | 2020-07-14T00:02:30Z | |
| dc.date.created | 2020-07-14T00:02:30Z | |
| dc.date.issued | 2020 | |
| dc.identifier | https://hdl.handle.net/20.500.12866/8319 | |
| dc.identifier | https://doi.org/10.1093/infdis/jiaa127 | |
| dc.description.abstract | To investigate the role of serum cytokine assays to distinguish between active from treated syphilis among serofast patients, we recruited individuals into a prospective cohort study. Participants underwent routine syphilis screening. We selected specimens from a majority cohort of serofast participants with treated and active syphilis. We analyzed specimens with a 62-cytokine multiplex bead-based enzyme-linked immunosorbent assay. Cytokines, BDNF and TNFB, were most predictive. We built a decision tree that was 82.4% accurate, 100% (95%CI: 82%-100%) sensitive, and 45% (95%CI, 18%-75%) specific. Our decision tree differentiated between serum specimens of serofast participants with treated syphilis and active syphilis. | |
| dc.language | eng | |
| dc.publisher | Oxford University Press | |
| dc.relation | Journal of Infectious Diseases | |
| dc.relation | 1537-6613 | |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.subject | cytokine | |
| dc.subject | tumor necrosis factors | |
| dc.subject | syphilis | |
| dc.subject | brain-derived neurotrophic factor | |
| dc.subject | decision trees | |
| dc.subject | serum specimen | |
| dc.title | The application of cytokine expression assays to differentiate active from previously treated syphilis. | |
| dc.type | info:eu-repo/semantics/article | |
