dc.date.accessioned | 2019-07-04T16:59:25Z | |
dc.date.available | 2019-07-04T16:59:25Z | |
dc.date.created | 2019-07-04T16:59:25Z | |
dc.date.issued | 2019 | |
dc.identifier | https://hdl.handle.net/20.500.12866/6751 | |
dc.identifier | https://doi.org/10.1016/j.earlhumdev.2019.01.019 | |
dc.description.abstract | Objective: To evaluate the combined prognostic value of neurological examination, head circumference and cranial ultrasound for neurodevelopmental delay (NDD) in very low birth weight (VLBW, <1500 g) preterm infants. Methods: Prospective follow-up study. Preterm infants with VLWB were assessed for NDD using the Mullen Scales of Early Learning test at 24 months of corrected age. Abnormal neurological examination (≥2 deviant items of Hammersmith neurological examination), microcephaly and major ultrasound abnormalities, each performed at term age, were evaluated as predictors of NDD in a multivariable Poisson model. Results: 35/132 infants (26.5%) had NDD. In the multivariable analysis, microcephaly (RR, 3.2; 95% CI, 1.6–6.7) and major ultrasound abnormalities (RR, 2.7; 95% CI, 1.3–5.7) were associated to NDD. The combination of the two tests showed the highest positive predictive value (100%; 95% CI, 51%–100%), while the combination of normal neurological examination, no major US findings and normal head size at term showed the highest negative predictive value (89%; 95% CI, 78%–95%). The maximum under receiver operating characteristic curve area was for microcephaly or major ultrasound abnormalities (AUC 0.74 (0.65–0.83)). Conclusion: The combination of head circumference, cranial ultrasound and neurological examination at term age is useful to predict NDD in VLBW preterm infants. | |
dc.language | eng | |
dc.publisher | Elsevier | |
dc.relation | Early Human Development | |
dc.relation | 1872-6232 | |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | adult | |
dc.subject | anthropometric parameters | |
dc.subject | Article | |
dc.subject | brain | |
dc.subject | Brain | |
dc.subject | brain development | |
dc.subject | cephalometry | |
dc.subject | cerebral palsy | |
dc.subject | clinical assessment | |
dc.subject | clinical evaluation | |
dc.subject | controlled study | |
dc.subject | developmental delay | |
dc.subject | Developmental Disabilities | |
dc.subject | developmental disorder | |
dc.subject | diagnostic imaging | |
dc.subject | double blind procedure | |
dc.subject | echography | |
dc.subject | evaluation study | |
dc.subject | female | |
dc.subject | Female | |
dc.subject | follow up | |
dc.subject | growth, development and aging | |
dc.subject | head circumference | |
dc.subject | human | |
dc.subject | Humans | |
dc.subject | infant | |
dc.subject | Infant, Newborn | |
dc.subject | Infant, Very Low Birth Weight | |
dc.subject | lactoferrin | |
dc.subject | learning test | |
dc.subject | major clinical study | |
dc.subject | male | |
dc.subject | Male | |
dc.subject | microcephaly | |
dc.subject | Mullen Scale of Early Learning Test | |
dc.subject | multicenter study | |
dc.subject | nerve cell differentiation | |
dc.subject | Neurodevelopment | |
dc.subject | neurodevelopmental delay | |
dc.subject | neuroimaging | |
dc.subject | neurologic examination | |
dc.subject | Neurologic Examination | |
dc.subject | newborn | |
dc.subject | outcome assessment | |
dc.subject | pathology | |
dc.subject | placebo | |
dc.subject | predictive value | |
dc.subject | Predictive value | |
dc.subject | Predictive Value of Tests | |
dc.subject | Predictors | |
dc.subject | Preterms | |
dc.subject | prognosis | |
dc.subject | prospective study | |
dc.subject | randomized controlled trial | |
dc.subject | receiver operating characteristic | |
dc.subject | standards | |
dc.subject | Ultrasonography | |
dc.subject | very low birth weight | |
dc.title | Combined predictors of neurodevelopment in very low birth weight preterm infants | |
dc.type | info:eu-repo/semantics/article | |