dc.date.accessioned2019-07-04T16:59:25Z
dc.date.available2019-07-04T16:59:25Z
dc.date.created2019-07-04T16:59:25Z
dc.date.issued2019
dc.identifierhttps://hdl.handle.net/20.500.12866/6751
dc.identifierhttps://doi.org/10.1016/j.earlhumdev.2019.01.019
dc.description.abstractObjective: To evaluate the combined prognostic value of neurological examination, head circumference and cranial ultrasound for neurodevelopmental delay (NDD) in very low birth weight (VLBW, <1500 g) preterm infants. Methods: Prospective follow-up study. Preterm infants with VLWB were assessed for NDD using the Mullen Scales of Early Learning test at 24 months of corrected age. Abnormal neurological examination (≥2 deviant items of Hammersmith neurological examination), microcephaly and major ultrasound abnormalities, each performed at term age, were evaluated as predictors of NDD in a multivariable Poisson model. Results: 35/132 infants (26.5%) had NDD. In the multivariable analysis, microcephaly (RR, 3.2; 95% CI, 1.6–6.7) and major ultrasound abnormalities (RR, 2.7; 95% CI, 1.3–5.7) were associated to NDD. The combination of the two tests showed the highest positive predictive value (100%; 95% CI, 51%–100%), while the combination of normal neurological examination, no major US findings and normal head size at term showed the highest negative predictive value (89%; 95% CI, 78%–95%). The maximum under receiver operating characteristic curve area was for microcephaly or major ultrasound abnormalities (AUC 0.74 (0.65–0.83)). Conclusion: The combination of head circumference, cranial ultrasound and neurological examination at term age is useful to predict NDD in VLBW preterm infants.
dc.languageeng
dc.publisherElsevier
dc.relationEarly Human Development
dc.relation1872-6232
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectadult
dc.subjectanthropometric parameters
dc.subjectArticle
dc.subjectbrain
dc.subjectBrain
dc.subjectbrain development
dc.subjectcephalometry
dc.subjectcerebral palsy
dc.subjectclinical assessment
dc.subjectclinical evaluation
dc.subjectcontrolled study
dc.subjectdevelopmental delay
dc.subjectDevelopmental Disabilities
dc.subjectdevelopmental disorder
dc.subjectdiagnostic imaging
dc.subjectdouble blind procedure
dc.subjectechography
dc.subjectevaluation study
dc.subjectfemale
dc.subjectFemale
dc.subjectfollow up
dc.subjectgrowth, development and aging
dc.subjecthead circumference
dc.subjecthuman
dc.subjectHumans
dc.subjectinfant
dc.subjectInfant, Newborn
dc.subjectInfant, Very Low Birth Weight
dc.subjectlactoferrin
dc.subjectlearning test
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectMale
dc.subjectmicrocephaly
dc.subjectMullen Scale of Early Learning Test
dc.subjectmulticenter study
dc.subjectnerve cell differentiation
dc.subjectNeurodevelopment
dc.subjectneurodevelopmental delay
dc.subjectneuroimaging
dc.subjectneurologic examination
dc.subjectNeurologic Examination
dc.subjectnewborn
dc.subjectoutcome assessment
dc.subjectpathology
dc.subjectplacebo
dc.subjectpredictive value
dc.subjectPredictive value
dc.subjectPredictive Value of Tests
dc.subjectPredictors
dc.subjectPreterms
dc.subjectprognosis
dc.subjectprospective study
dc.subjectrandomized controlled trial
dc.subjectreceiver operating characteristic
dc.subjectstandards
dc.subjectUltrasonography
dc.subjectvery low birth weight
dc.titleCombined predictors of neurodevelopment in very low birth weight preterm infants
dc.typeinfo:eu-repo/semantics/article


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