Exercise heart rates in patients with hypertrophic cardiomyopathy

dc.date.accessioned2019-04-24T18:23:49Z
dc.date.available2019-04-24T18:23:49Z
dc.date.created2019-04-24T18:23:49Z
dc.date.issued2015
dc.identifierhttps://hdl.handle.net/20.500.12866/6457
dc.identifierhttps://doi.org/10.1016/j.amjcard.2015.01.548
dc.description.abstractThe exercise heart rate (HR) profile and its relation to cardiac function and arrhythmias were investigated in patients with hypertrophic cardiomyopathy (HC). Chronotropic response (CR) and heart rate recovery (HRR) were computed during and after treadmill exercise testing in 273 patients with HC and 95 age-matched healthy controls. Patients with HC had higher prevalence of chronotropic incompetence and lower HRR1-5min compared with controls. Exercise capacity, diastolic function (assessed by E/e') and left atrial volume index were associated with HRR1min and CR in HC. Septal myectomy was associated with reduction in chronotropic incompetence but did not affect HRR1min. In conclusion, impaired CR and HRR1min are associated with advanced disease and do not appear to be independent clinical markers indicating high-risk status in HC. Improving CR by titrating doses of negative chronotropic agents, myectomy, and atrial pacing may be useful to increase exercise capacity in patients with HC.
dc.languageeng
dc.publisherElsevier
dc.relationAmerican Journal of Cardiology
dc.relation1879-1913
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectadult
dc.subjectArticle
dc.subjectchronotropism
dc.subjectcontrolled study
dc.subjectdiastole
dc.subjectexercise
dc.subjectfemale
dc.subjectheart function
dc.subjectheart left atrium
dc.subjectheart rate
dc.subjectheart rate recovery
dc.subjectheart volume
dc.subjecthuman
dc.subjecthypertrophic cardiomyopathy
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmuscle resection
dc.subjectpriority journal
dc.subjecttreadmill exercise
dc.subjectCardiomyopathy, Hypertrophic
dc.subjectcomputer assisted tomography
dc.subjectconvalescence
dc.subjectDoppler echocardiography
dc.subjectelectrocardiography
dc.subjectexercise
dc.subjectexercise test
dc.subjectfollow up
dc.subjectheart left ventricle function
dc.subjectheart rate
dc.subjectheart ventricle
dc.subjectmiddle aged
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectpositron emission tomography
dc.subjectprocedures
dc.subjectprognosis
dc.subjectretrospective study
dc.subjectseverity of illness index
dc.subjectCardiomyopathy, Hypertrophic
dc.subjectEchocardiography, Doppler, Color
dc.subjectElectrocardiography
dc.subjectExercise
dc.subjectExercise Test
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHeart Rate
dc.subjectHeart Ventricles
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPositron-Emission Tomography
dc.subjectPrognosis
dc.subjectRecovery of Function
dc.subjectRetrospective Studies
dc.subjectSeverity of Illness Index
dc.subjectTomography, X-Ray Computed
dc.subjectVentricular Function, Left
dc.titleExercise heart rates in patients with hypertrophic cardiomyopathy
dc.typeinfo:eu-repo/semantics/article


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