dc.date.accessioned2019-02-06T14:53:12Z
dc.date.available2019-02-06T14:53:12Z
dc.date.created2019-02-06T14:53:12Z
dc.date.issued2015
dc.identifierhttps://hdl.handle.net/20.500.12866/5407
dc.identifierhttps://doi.org/10.1098/rspb.2014.2807
dc.description.abstractFaeces-mediated transmission of Trypanosoma cruzi (the aetiological agent of Chagas disease) by triatomine insects is extremely inefficient. Still, the parasite emerges frequently, and has infected millions of people and domestic animals. We synthesize here the results of field and laboratory studies of T. cruzi transmission conducted in and around Arequipa, Peru. We document the repeated occurrence of large colonies of triatomine bugs (more than 1000) with very high infection prevalence (more than 85%). By inoculating guinea pigs, an important reservoir of T. cruzi in Peru, and feeding triatomine bugs on them weekly, we demonstrate that, while most animals quickly control parasitaemia, a subset of animals remains highly infectious to vectors for many months. However, we argue that the presence of these persistently infectious hosts is insufficient to explain the observed prevalence of T. cruzi in vector colonies. We posit that seasonal rains, leading to a fluctuation in the price of guinea pig food (alfalfa), leading to annual guinea pig roasts, leading to a concentration of vectors on a small subpopulation of animals maintained for reproduction, can propel T. cruzi through vector colonies and create a considerable force of infection for a pathogen whose transmission might otherwise fizzle out.
dc.languageeng
dc.publisherRoyal Society Publishing
dc.relationProceedings - Royal Society. Biological Sciences
dc.relation1471-2954
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectTrypanosoma cruzi
dc.subjectCross-Sectional Studies
dc.subjectPeru/epidemiology
dc.subjectAnimals
dc.subjectPopulation Dynamics
dc.subjectPrevalence
dc.subjectChagas disease
dc.subjectTriatoma infestans
dc.subjectTrypanosoma cruzi/physiology
dc.subjectGuinea Pigs
dc.subjectbottleneck
dc.subjectChagas Disease/epidemiology/parasitology/transmission/veterinary
dc.subjectDisease Reservoirs/parasitology/veterinary
dc.subjectguinea pigs
dc.subjectInsect Vectors/parasitology/physiology
dc.subjectParasitemia/epidemiology/parasitology/transmission/veterinary
dc.subjectRodent Diseases/epidemiology/parasitology/transmission
dc.subjectTriatoma/parasitology/physiology
dc.titleBottlenecks in domestic animal populations can facilitate the emergence of Trypanosoma cruzi, the aetiological agent of Chagas disease
dc.typeinfo:eu-repo/semantics/article


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