dc.date.accessioned2019-01-25T16:59:38Z
dc.date.available2019-01-25T16:59:38Z
dc.date.created2019-01-25T16:59:38Z
dc.date.issued2017
dc.identifierhttps://hdl.handle.net/20.500.12866/4903
dc.identifierhttps://doi.org/10.1080/1744666X.2017.1327352
dc.description.abstractINTRODUCTION: Systemic lupus erythematosus (SLE) is a disease distributed worldwide, which occurs in both genders, and across racial/ethnic and age groups; however, higher rates are observed in adults, in women and in non-Caucasians. Genetic, environmental, sociodemographic and methodological issues are responsible not only for these differences but for the variable course and outcome of the disease. Non-Caucasians have a more severe disease with a higher risk for early mortality and damage accrual. Males also have a more severe disease; however, a negative impact of male gender on lupus outcomes has not been firmly established. Childhood-onset is associated with a more severe disease; moreover, it is also associated with higher damage and diminished survival; finally, late-onset lupus is mild but it is associated with higher damage accrual and a diminished survival. Areas covered: In this review, we discuss the incidence and prevalence of SLE, the impact of age, gender and race/ethnicity in SLE and in the survival of those affected. Expert commentary: Age, gender and race/ethnicity impact disease expression in SLE patients; despite improvements in survival, mortality in SLE remains almost three times higher than in the general population.
dc.languageeng
dc.publisherTaylor and Francis
dc.relationExpert Review of Clinical Immunology
dc.relation1744-8409
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectSurvival Analysis
dc.subjectRisk Factors
dc.subjectPrevalence
dc.subjectIncidence
dc.subjectDisease Progression
dc.subjectage
dc.subjectAge Factors
dc.subjectContinental Population Groups
dc.subjectepidemiology
dc.subjectgender
dc.subjectincidence
dc.subjectprevalence
dc.subjectrace /ethnicity
dc.subjectSex Factors
dc.subjectsurvival /mortality
dc.subjectSystemic lupus erythematosus
dc.subjectAge of Onset
dc.subjectLupus Erythematosus, Systemic/epidemiology/mortality
dc.subjectUnited States/epidemiology
dc.titleEpidemiology of systemic lupus erythematosus
dc.typeinfo:eu-repo/semantics/review


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