dc.date.accessioned | 2019-01-25T16:59:38Z | |
dc.date.available | 2019-01-25T16:59:38Z | |
dc.date.created | 2019-01-25T16:59:38Z | |
dc.date.issued | 2017 | |
dc.identifier | https://hdl.handle.net/20.500.12866/4903 | |
dc.identifier | https://doi.org/10.1080/1744666X.2017.1327352 | |
dc.description.abstract | INTRODUCTION: Systemic lupus erythematosus (SLE) is a disease distributed worldwide, which occurs in both genders, and across racial/ethnic and age groups; however, higher rates are observed in adults, in women and in non-Caucasians. Genetic, environmental, sociodemographic and methodological issues are responsible not only for these differences but for the variable course and outcome of the disease. Non-Caucasians have a more severe disease with a higher risk for early mortality and damage accrual. Males also have a more severe disease; however, a negative impact of male gender on lupus outcomes has not been firmly established. Childhood-onset is associated with a more severe disease; moreover, it is also associated with higher damage and diminished survival; finally, late-onset lupus is mild but it is associated with higher damage accrual and a diminished survival. Areas covered: In this review, we discuss the incidence and prevalence of SLE, the impact of age, gender and race/ethnicity in SLE and in the survival of those affected. Expert commentary: Age, gender and race/ethnicity impact disease expression in SLE patients; despite improvements in survival, mortality in SLE remains almost three times higher than in the general population. | |
dc.language | eng | |
dc.publisher | Taylor and Francis | |
dc.relation | Expert Review of Clinical Immunology | |
dc.relation | 1744-8409 | |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Survival Analysis | |
dc.subject | Risk Factors | |
dc.subject | Prevalence | |
dc.subject | Incidence | |
dc.subject | Disease Progression | |
dc.subject | age | |
dc.subject | Age Factors | |
dc.subject | Continental Population Groups | |
dc.subject | epidemiology | |
dc.subject | gender | |
dc.subject | incidence | |
dc.subject | prevalence | |
dc.subject | race /ethnicity | |
dc.subject | Sex Factors | |
dc.subject | survival /mortality | |
dc.subject | Systemic lupus erythematosus | |
dc.subject | Age of Onset | |
dc.subject | Lupus Erythematosus, Systemic/epidemiology/mortality | |
dc.subject | United States/epidemiology | |
dc.title | Epidemiology of systemic lupus erythematosus | |
dc.type | info:eu-repo/semantics/review | |