| dc.description.abstract | Background: In 1927, Burrows and Farr demonstrated an interaction between b-carotenes
and mineral oil (laxative), but it was not until 2000 that the importance of this type of
interactions was recognized, considering them as a public health problem (1,2), which can
potentiate or inhibit the pharmacological effect of the drug with significant clinical relevance
(3,5). Therefore, it is essential to have sufficient data in order to provide an adequate
prescription that achieves a successful treatment.
Objective: to synthesize the scientific evidence on the clinically relevant aspects of the drug-
nutrient and drug-medicinal plant interactions in the pharmacological treatment of
hypertension with losartan.
Methodology: Qualitative systematic review of primary origin articles on the reported
interactions between nutrients or medicinal plants and losartan.
Results: When the search equations were applied, 283 articles were reached, and three
that met the inclusion criteria were analyzed. In the first, no interaction was reported
between losartan and red ginseng, in the second there is an interaction of increased toxicity
between Rhodiola rosea and losartan, finally in the third, a pharmacokinetic absorption
interaction was reported between losartan and a diet rich in fat and calories.
Conclusions: The administration of losartan with the medicinal plant Rhodiola rosea and a
food rich in fats and calories causes pharmacokinetic-type drug interactions, increasing the
absorption of the drug and, consequently, generating toxicity associated with high plasma
concentrations.
Keywords: High blood pressure. Losartan. Drug interaction. Drug-nutrient interaction. Drug-
medicinal plant interaction. | |
