dc.contributor | Intriago Morales, Ruth Viviana | |
dc.creator | Gavidia Pazmiño, Jonathan Francisco | |
dc.creator | Bravo Guapisaca, María Isabel | |
dc.date.accessioned | 2022-02-14T14:40:24Z | |
dc.date.accessioned | 2022-10-20T21:40:55Z | |
dc.date.available | 2022-02-14T14:40:24Z | |
dc.date.available | 2022-10-20T21:40:55Z | |
dc.date.created | 2022-02-14T14:40:24Z | |
dc.date.issued | 2022-02-11 | |
dc.identifier | http://dspace.ucuenca.edu.ec/handle/123456789/38051 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4605058 | |
dc.description.abstract | Background: Hundreds of adipokines have been identified, and their extensive range of
endocrine functions—regulating distant organs such as oral tissues—and local
autocrine/paracrine roles have been studied. In dentistry, however, adipokines are poorly
known proteins in the dental pulp; few of them have been studied despite their large
number. This study reviews recent advances in the investigation of dental-pulp
adipokines, with an emphasis on their roles in inflammatory processes and their potential
therapeutic applications.
Highlights: The most recently identified adipokines in dental pulp include leptin,
adiponectin, resistin, ghrelin, oncostatin, chemerin, and visfatin. They have numerous
physiological and pathological functions in the pulp tissue: they are closely related to pulp
inflammatory mechanisms and actively participate in cell differentiation, mineralization,
angiogenesis, and immune-system modulation.
Conclusion: Adipokines have potential clinical applications in regenerative endodontics
and as biomarkers or targets for the pharmacological management of inflammatory and
degenerative processes in dental pulp. A promising direction for the development of new
therapies may be the use of agonists/antagonists to modulate the expression of the most
studied adipokines. | |
dc.language | eng | |
dc.publisher | Universidad de Cuenca | |
dc.relation | ODONEN;017 | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.rights | openAccess | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | |
dc.subject | Odontología | |
dc.subject | Patología oral | |
dc.title | Adipokines in dental pulp: physiological, pathological and potential therapeutic roles | |
dc.type | masterThesis | |