dc.creatorCastañeda Alvarado, Cristina Paola
dc.creatorAlvarez Vasquez, Jose Luis
dc.date.accessioned2022-06-08T17:16:02Z
dc.date.accessioned2022-10-20T21:22:28Z
dc.date.available2022-06-08T17:16:02Z
dc.date.available2022-10-20T21:22:28Z
dc.date.created2022-06-08T17:16:02Z
dc.date.issued2022
dc.identifier0099-2399
dc.identifierhttp://dspace.ucuenca.edu.ec/handle/123456789/39078
dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0099239922003417
dc.identifier10.1016/j.joen.2022.05.004
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4602884
dc.description.abstractIntroduction Dental pulp fibroblasts (DPF) are the most abundant cell type in the dental pulp. They play pivotal roles; however, they are often mistaken to be involved only in the repair and maintenance of this connective tissue. Methods We used the search terms “pulp fibroblast,” “complement system proteins,” “pulp inflammation,” “angiogenesis,” and “dentin pulp regeneration” to identify articles from the PubMed and Scopus databases. Result These sentinel cells produce all complement system proteins participating in defense processes, control of inflammation, and dentin-pulp regeneration; produce several proinflammatory cytokines and chemokines and express pattern-recognition receptors, demonstrating their involvement in immunoregulatory mechanisms; express neuropeptides and their receptors, playing an important role in neurogenic inflammation and dental pulp wound healing; secrete angiogenic growth factors as well as neurotrophic proteins, essential for dentin-pulp regeneration; regulate neuronal plasticity processes; and can sense the external environment. Conclusion This review highlights that DPFs are more than mere passive cells in pulp biology and presents an integrative analysis of their roles and functions.
dc.languagees_ES
dc.sourceJournal of Endodontics
dc.subjectFibroblasts
dc.subjectComplement system proteins
dc.subjectDental pulp disease
dc.subjectRegenerative endodontics
dc.subjectDental pulp
dc.titleDental pulp fibroblast: a star cell
dc.typeARTÍCULO


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