| dc.description.abstract | Proton pump inhibitors (PPIs) are a pharmacological group used worldwide, where their
prescription or self-medication has increased considerably, which has aroused the interest of
the medical and scientific community, due to the appearance of diverse negative safety results
associated with the medication (NRM). In this context, the aim of this research was to determine
the clinically important negative safety outcomes associated with the long term use of PPIs. For
this purpose, a literature search and review were performed, which included 66 observational
studies, published between 2000 and 2021, which were retrieved from the following databases:
Cochrane library, Base Search, Google Scholar, PubMed, ScienceDirect, Scopus and Springer
link. The results obtained from the bibliographic review indicated that, after the use more than
1 year of proton pump inhibitor, the most reported safety problems were: risk of developing
fractures (25,76%), chronic kidney disease (12,12%) and Clostridium difficile infections
(10,61%). In smaller proportions: respiratory infections, cancer, fundic gland polyps,
hypomagnesemia, infectious gastritis, cholangitis, AKI, kidney stones, iron deficiency, vitamin
B12 deficiency, pyogenic liver abscess were reported as possible risks due to prolonged use of
PPIs. In addition, the studies indicated a higher prevalence in older adults, where the female
gender was the most affected, representing 55,6% of the patients. From the literature review, it
is concluded that the prolonged use of PPIs may increase the risk of the aforementioned safety
NRM, thus recommending greater vigilance in the use of these drugs. | |
