dc.creator | Arias Arias, Jorge Luis | |
dc.creator | Vega Aguilar, Francisco | |
dc.creator | Picado Soto, Dihalá | |
dc.creator | Corrales Aguilar, Eugenia | |
dc.creator | Loría Masís, Gilbert David | |
dc.date.accessioned | 2022-07-19T22:00:13Z | |
dc.date.accessioned | 2022-10-19T23:50:37Z | |
dc.date.available | 2022-07-19T22:00:13Z | |
dc.date.available | 2022-10-19T23:50:37Z | |
dc.date.created | 2022-07-19T22:00:13Z | |
dc.date.issued | 2021-09-15 | |
dc.identifier | https://www.mdpi.com/journal/microbiolres | |
dc.identifier | 2036-7481 | |
dc.identifier | https://hdl.handle.net/10669/86986 | |
dc.identifier | . https://doi.org/10.3390/microbiolres12030052 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4524707 | |
dc.description.abstract | Zika virus (ZIKV) is a mosquito-borne flavivirus in which human infection became relevant
during recent outbreaks in Latin America due to its unrecognized association with fetal neurological
disorders. Currently, there are no approved effective antivirals or vaccines for the treatment or
prevention of ZIKV infections. Amantadine and rimantadine are approved antivirals used against
susceptible influenza A virus infections that have been shown to have antiviral activity against other
viruses, such as dengue virus (DENV). Here, we report the in vitro effectiveness of both amantadine
and rimantadine hydrochlorides against ZIKV replication, resulting in a dose-dependent reduction
in viral titers of a ZIKV clinical isolate and two different ZIKV reference strains. Additionally, we
demonstrate similar in vitro antiviral activity of these drugs against DENV-1 and yellow fever virus
(YFV), although at higher drug concentrations for the latter. ZIKV replication was inhibited at drug
concentrations well below cytotoxic levels of both compounds, as denoted by the high selectivity
indexes obtained with the tested strains. Further work is absolutely needed to determine the potential
clinical use of these antivirals against ZIKV infections, but our results suggest the existence of a
highly conserved mechanism across flavivirus, susceptible to be blocked by modified more specific
adamantane compounds. | |
dc.language | eng | |
dc.source | Mocrobiology Research, 12, 2021 | |
dc.subject | Zika | |
dc.subject | dengue | |
dc.subject | yellow fever | |
dc.subject | antivirals | |
dc.subject | adamantanes | |
dc.subject | amantadine | |
dc.subject | rimantadine | |
dc.title | In Vitro Inhibition of Zika Virus Replication with Amantadine and Rimantadine Hydrochlorides | |
dc.type | artículo científico | |