dc.creatorCastillo Henríquez, Luis
dc.creatorMadrigal Redondo, German
dc.creatorVargas Zúñiga, Rolando
dc.creatorCarazo Berrocal, Gustavo
dc.date.accessioned2020-04-28T20:19:43Z
dc.date.accessioned2022-10-19T23:33:16Z
dc.date.available2020-04-28T20:19:43Z
dc.date.available2022-10-19T23:33:16Z
dc.date.created2020-04-28T20:19:43Z
dc.date.issued2018
dc.identifierhttps://www.journalajst.com/identification-rupatadine-fumarate-polymorphic-crystalline-forms-pharmaceutical-raw-materials
dc.identifier0976-3376
dc.identifierhttps://hdl.handle.net/10669/80938
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4519487
dc.description.abstractPolymorphism analysis of pharmaceutical raw materials is considered one of the most relevant evaluations that should be done. As we know, different crystal forms from the same molecule have differences in terms of their physicochemical properties. According to the crystal form used, researchers can obtain benefits for the development of a new product or it can also imply a disadvantage for the formulation of the product. The present study focuses on the identification of crystalline forms in Rupatadine Fumarate raw material samples. The active pharmaceutical ingredient is an antihistaminic, classified as a second-generation selective H1 receptor, which shows advantages in terms of solubility in contrast with the free base and the trichloride form. Analytical techniques employed were: X ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and infrared spectroscopy. The results were analyzed all together and compared with the information found in literature. Based on the results obtained, it was demonstrated that the analyzed drug samples don´t present any other polymorphic form besides A form, which is the only one reported in literature.
dc.languageen_US
dc.sourceAsian Journal of Science and Technology, vol.09(02), pp.7482-7487
dc.subjectActive pharmaceutical Ingredient
dc.subjectAntihistaminic
dc.subjectDifferential scanning
dc.subjectCalorimetry
dc.subjectInfrared spectroscopy
dc.subjectPharmaceutical polymorphism
dc.subjectRupatadine fumarate
dc.subjectThermogravimetric analysis
dc.subjectX ray diffraction
dc.titleIdentification of rupatadine fumarate polymorphic crystalline forms in pharmaceutical raw materials
dc.typeartículo científico


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