Solubility of losartan potassium in several mono-solvents at different temperatures

dc.creator	Eghrary, Shadi H.
dc.creator	Zarghami, Reza
dc.creator	Jouyban, Abolghasem
dc.date	2012
dc.date	2012-08-28T12:05:19Z
dc.identifier	http://sedici.unlp.edu.ar/handle/10915/20210
dc.identifier	http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_2_5.pdf
dc.identifier	issn:0326-2383
dc.description	The solubilities of losartan potassium in eight solvents; 1,4-dioxane, acetonitrile, propylene glycol, N-methyl-2-pyrrolidone, 1-butanol, 1-hexanol, 1-heptanol, and 1-octanol, were measured at temperatures ranging from 293.2 to 318.2 K at atmospheric pressure using shake-flask method of Higuchi and Connors. N-methyl-2-pyrrolidone dissolved the highest amount of losartan potassium and 1,4-dioxane possessed the lowest solubilization power among the investigated solvents. The generated data was used to calculate the thermodynamic parameters of the system using the modified van’t Hoff equation and the Gibbs free energy data was correlated using Abraham solvation parameters.
dc.description	Colegio de Farmacéuticos de la Provincia de Buenos Aires
dc.format	application/pdf
dc.format	632-636
dc.language	en
dc.relation	Latin American Journal of Pharmacy
dc.relation	vol. 31, no. 4
dc.subject	Farmacia
dc.title	Solubility of losartan potassium in several mono-solvents at different temperatures
dc.type	Articulo
dc.type	Comunicacion